Hypertriglyceridemic waist, cytokines and hyperglycaemia in Chinese

Zhijie Yu, Liang Sun, Qibin Qi, Hongyu Wu, Ling Lu, Chen Liu, Huaixing Li, Xu Lin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background Abdominal obesity and hypertriglyceridemia confer high risk for cardiometabolic disease. Few studies have investigated the associations of hypertriglyceridemic waist with cytokines and hyperglycaemia in Chinese. Methods Anthropometric indexes, fasting plasma concentrations of glucose, glycohemoglobin, insulin, lipid profile, inflammatory factors and adipokines were measured among 3289 Chinese men and women 50-70years of age. Results An increment of every 2cm of waist circumference was associated with increased levels of high-sensitive C-reactive protein (hsCRP), interleukin 6 and RBP 4 by 0·033mg/L, 0·018ng/L and 0·556mg/L and reduced levels of adiponectin by 0·269mg/L (all P<0·05), respectively, with controlling for potential confounders. For triglycerides, each an increment of 20mg/dL was associated with increased levels of hsCRP, RBP4, and decreased levels of adiponectin by 0·021mg/L, 0·655mg/L, and 0·371mg/L (all P<0·05), respectively. Individuals with hypertriglyceridemic waist had increased risks of having hyperglycaemia (OR: 1·48; 95% CI: 1·09, 2·00) and diabetes mellitus (OR: 2·12; 95% CI: 1·47, 3·04) compared with those with neither of the phenotypes. Conclusions Hypertriglyceridemic waist is associated with a worse profile of inflammatory factors and adipokines as well as with an increased risk of having hyperglycaemia among Chinese.

Original languageEnglish (US)
Pages (from-to)1100-1111
Number of pages12
JournalEuropean Journal of Clinical Investigation
Volume42
Issue number10
DOIs
StatePublished - Oct 2012
Externally publishedYes

Fingerprint

Hypertriglyceridemic Waist
Hyperglycemia
Adipokines
Adiponectin
Cytokines
C-Reactive Protein
Abdominal Obesity
Hypertriglyceridemia
Waist Circumference
Medical problems
Interleukin-6
Fasting
Diabetes Mellitus
Triglycerides
Insulin
Phenotype
Lipids
Plasmas
Glucose

Keywords

  • Adipokines
  • Hyperglycaemia
  • Hypertriglyceridemic waist
  • Inflammatory factors

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Biochemistry
  • Biochemistry

Cite this

Hypertriglyceridemic waist, cytokines and hyperglycaemia in Chinese. / Yu, Zhijie; Sun, Liang; Qi, Qibin; Wu, Hongyu; Lu, Ling; Liu, Chen; Li, Huaixing; Lin, Xu.

In: European Journal of Clinical Investigation, Vol. 42, No. 10, 10.2012, p. 1100-1111.

Research output: Contribution to journalArticle

Yu, Zhijie ; Sun, Liang ; Qi, Qibin ; Wu, Hongyu ; Lu, Ling ; Liu, Chen ; Li, Huaixing ; Lin, Xu. / Hypertriglyceridemic waist, cytokines and hyperglycaemia in Chinese. In: European Journal of Clinical Investigation. 2012 ; Vol. 42, No. 10. pp. 1100-1111.
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