Hyperthermia on immune regulation

A temperature's story

Hua Gang Zhang, Keyur J. Mehta, Patrice Cohen, Chandan Guha

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory effect on different sensitive targets. Understanding these intrinsic mechanisms could bring new inspirations on the design of clinical trials combining local tumor hyperthermia with immunotherapy in cancer patients. This review will attempt to tell the story about the effect of temperature on immune regulation, with special emphasis on the clinical application of hyperthermia and the feasibility of combining it with immunotherapy in the clinic.

Original languageEnglish (US)
Pages (from-to)191-204
Number of pages14
JournalCancer Letters
Volume271
Issue number2
DOIs
StatePublished - Nov 28 2008

Fingerprint

Fever
Temperature
Immunotherapy
Induced Hyperthermia
Heat-Shock Proteins
Heating
Immune System
Neoplasms
Clinical Trials

Keywords

  • Heat shock protein
  • Hyperthermia
  • Immunomodulation
  • Immunotherapy
  • Tumor vaccine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hyperthermia on immune regulation : A temperature's story. / Zhang, Hua Gang; Mehta, Keyur J.; Cohen, Patrice; Guha, Chandan.

In: Cancer Letters, Vol. 271, No. 2, 28.11.2008, p. 191-204.

Research output: Contribution to journalArticle

Zhang, Hua Gang ; Mehta, Keyur J. ; Cohen, Patrice ; Guha, Chandan. / Hyperthermia on immune regulation : A temperature's story. In: Cancer Letters. 2008 ; Vol. 271, No. 2. pp. 191-204.
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