Hyperthermia on immune regulation: A temperature's story

Hua Gang Zhang, Keyur Mehta, Patrice Cohen, Chandan Guha

Research output: Contribution to journalReview articlepeer-review

106 Scopus citations


Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory effect on different sensitive targets. Understanding these intrinsic mechanisms could bring new inspirations on the design of clinical trials combining local tumor hyperthermia with immunotherapy in cancer patients. This review will attempt to tell the story about the effect of temperature on immune regulation, with special emphasis on the clinical application of hyperthermia and the feasibility of combining it with immunotherapy in the clinic.

Original languageEnglish (US)
Pages (from-to)191-204
Number of pages14
JournalCancer Letters
Issue number2
StatePublished - Nov 28 2008


  • Heat shock protein
  • Hyperthermia
  • Immunomodulation
  • Immunotherapy
  • Tumor vaccine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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