Hypertensive crises induced by treatment of malignant pheochromocytoma with a combination of cyclophosphamide, vincristine, and dacarbazine

Li‐Teh ‐T Wu, Peter Dicpinigaitis, Howard Bruckner, William Manger, Steven Averbuch

Research output: Contribution to journalArticle

17 Scopus citations


Combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine (CVD) is an effective treatment regimen for malignant pheochromocytoma. There have not been any significant acute cardiovascular effects reported following CVD treatment. Among seven patients with malignant pheochromocytoma treated with CVD at our institution, two patients with labile hypertension developed hypertensive crises following CVD treatment. The marked increase in blood pressure correlated with an increase in urinary excretion of catecholamine metabolites in one patient. Further hypertensive crises following sebsequent CVD treatments were avoided by optimizing each patient's antiadrenergic therapy. Similar to the approach used preoperatively for patients with resectable pheochromocytoma, maximal antiadrenergic therapy is essential in preventing hypertensive crises in patients with malignant pheochromocytoma undergoing CVD treatment. © 1994 wiley‐Liss, inc.

Original languageEnglish (US)
Pages (from-to)389-392
Number of pages4
JournalMedical and Pediatric Oncology
Issue number6
Publication statusPublished - 1994
Externally publishedYes



  • Key words
  • chemotherapy
  • cyclophosphamide
  • dacarbazine
  • hypertensive crises
  • malignant pheochromocytoma
  • vincristine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

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