Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL)

Abraham M.Y. Nomura, Eugene T. Yanagihara, William A. Blattner, Gloria Y.F. Ho, Melvin S. Inamasu, Richard K. Severson, Jeffrey M. Nakamura

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Abstract

In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non‐Hodgkin's lymphoma were identified after a follow‐up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T‐cell leukemia/lymphoma (ATL). Both of these brothers had human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV‐I antibody positive. This finding lends further support for a role of HTLV‐I in the etiology of adult T‐cell leukemia/lymphoma.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalHematological Oncology
Volume8
Issue number3
DOIs
Publication statusPublished - Jan 1 1990

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Keywords

  • Familial ATL
  • HTLV‐I Antibodies
  • Leukemia
  • Lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Nomura, A. M. Y., Yanagihara, E. T., Blattner, W. A., Ho, G. Y. F., Inamasu, M. S., Severson, R. K., & Nakamura, J. M. (1990). Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL). Hematological Oncology, 8(3), 169-176. https://doi.org/10.1002/hon.2900080308