TY - JOUR
T1 - Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL)
AU - Nomura, Abraham M.Y.
AU - Yanagihara, Eugene T.
AU - Blattner, William A.
AU - Ho, Gloria Y.F.
AU - Inamasu, Melvin S.
AU - Severson, Richard K.
AU - Nakamura, Jeffrey M.
PY - 1990
Y1 - 1990
N2 - In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non‐Hodgkin's lymphoma were identified after a follow‐up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T‐cell leukemia/lymphoma (ATL). Both of these brothers had human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV‐I antibody positive. This finding lends further support for a role of HTLV‐I in the etiology of adult T‐cell leukemia/lymphoma.
AB - In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non‐Hodgkin's lymphoma were identified after a follow‐up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T‐cell leukemia/lymphoma (ATL). Both of these brothers had human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV‐I antibody positive. This finding lends further support for a role of HTLV‐I in the etiology of adult T‐cell leukemia/lymphoma.
KW - Familial ATL
KW - HTLV‐I Antibodies
KW - Leukemia
KW - Lymphoma
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U2 - 10.1002/hon.2900080308
DO - 10.1002/hon.2900080308
M3 - Article
C2 - 2373493
AN - SCOPUS:0025046745
SN - 0278-0232
VL - 8
SP - 169
EP - 176
JO - Hematological Oncology
JF - Hematological Oncology
IS - 3
ER -