TY - JOUR
T1 - Human t lymphotropic virus type ii (Htlv-ii) infection in a cohort of new york intravenous drug users
T2 - An old infection?
AU - Khabbaz, Rima F.
AU - Hartel, Diana
AU - Lairmore, Michael
AU - Horsburgh, C. Robert
AU - Schoenbaum, Ellie E.
AU - Roberts, Beverly
AU - Hartley, Trudie M.
AU - Friedland, Gerald
PY - 1991/2
Y1 - 1991/2
N2 - To identify risk factors for human T lymphotropic virus type II (HTLV-II) infection in intravenous drug users (IVDUs), participants in a longitudinal study of human immunodeficiency virus (HIV) infection in a New York methadone maintenance program were studied.Of 270 participants tested for HTLV-I/II, 21 (8%) were seropositive.Of those, 15 (71%) had HTLV- Il-specific sequences by polymerase chain reaction (PCR) and 1 (5%) had both HTLV-I- and -Il-specific sequences; 3 persons with indeterminate serologic results were also PCR-positive for HTLV-II.HTLV-II infection was significantly associated with older age but was not predicted by sex, race, socioeconomic status, transfusion history, or HIV infection status.Behavioral factors since 1978, such as duration and frequency of intravenous drug use, needle sharing, visits to shooting galleries, or number of sex partners, were also not associated with HTLV-II infection.These findings are in contrast with the association of these risk factors with HIV in this group and suggest that, among IVDUs, HTLV-II is an older endemic infection that is less efficiently transmitted than HIV.
AB - To identify risk factors for human T lymphotropic virus type II (HTLV-II) infection in intravenous drug users (IVDUs), participants in a longitudinal study of human immunodeficiency virus (HIV) infection in a New York methadone maintenance program were studied.Of 270 participants tested for HTLV-I/II, 21 (8%) were seropositive.Of those, 15 (71%) had HTLV- Il-specific sequences by polymerase chain reaction (PCR) and 1 (5%) had both HTLV-I- and -Il-specific sequences; 3 persons with indeterminate serologic results were also PCR-positive for HTLV-II.HTLV-II infection was significantly associated with older age but was not predicted by sex, race, socioeconomic status, transfusion history, or HIV infection status.Behavioral factors since 1978, such as duration and frequency of intravenous drug use, needle sharing, visits to shooting galleries, or number of sex partners, were also not associated with HTLV-II infection.These findings are in contrast with the association of these risk factors with HIV in this group and suggest that, among IVDUs, HTLV-II is an older endemic infection that is less efficiently transmitted than HIV.
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U2 - 10.1093/infdis/163.2.252
DO - 10.1093/infdis/163.2.252
M3 - Article
C2 - 1988509
AN - SCOPUS:0025976727
SN - 0022-1899
VL - 163
SP - 252
EP - 256
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -
