Human T-Cell Lymphotropic Virus Type III (HTLV-III) Embryopathy: A New Dysmorphic Syndrome Associated With Intrauterine HTLV-III Infection

Robert W. Marion, R. Gordon Hutcheon, Arye Rubinstein

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Twenty infants and children with positive serologic tests for the human T-cell lymphotropic virus type III (HTLV-III) were noted to have similar features including growth failure (75%), microcephaly (70%), and craniofacial abnormalities consisting of ocular hypertelorism (50%); prominent box-like appearance of the forehead (75%); flat nasal bridge (70%); mild upward or downward obliquity of the eyes (65%); long palpebral fissures with blue sclerae (60%); short nose with flattened columella and well-formed, triangular philtrum (65%); and patulous lips (60%). These features constitute a new and distinct dysmorphic syndrome, the HTLV-III embryopathy.

Original languageEnglish (US)
Pages (from-to)638-640
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume140
Issue number7
DOIs
StatePublished - 1986

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Fetal Diseases
Lip
Nose
HIV Infections
Craniofacial Abnormalities
HIV
Hypertelorism
Microcephaly
Sclera
Forehead
Serologic Tests
Eyelids
Growth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Human T-Cell Lymphotropic Virus Type III (HTLV-III) Embryopathy: A New Dysmorphic Syndrome Associated With Intrauterine HTLV-III Infection",
abstract = "Twenty infants and children with positive serologic tests for the human T-cell lymphotropic virus type III (HTLV-III) were noted to have similar features including growth failure (75{\%}), microcephaly (70{\%}), and craniofacial abnormalities consisting of ocular hypertelorism (50{\%}); prominent box-like appearance of the forehead (75{\%}); flat nasal bridge (70{\%}); mild upward or downward obliquity of the eyes (65{\%}); long palpebral fissures with blue sclerae (60{\%}); short nose with flattened columella and well-formed, triangular philtrum (65{\%}); and patulous lips (60{\%}). These features constitute a new and distinct dysmorphic syndrome, the HTLV-III embryopathy.",
author = "Marion, {Robert W.} and Hutcheon, {R. Gordon} and Arye Rubinstein",
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AU - Rubinstein, Arye

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AB - Twenty infants and children with positive serologic tests for the human T-cell lymphotropic virus type III (HTLV-III) were noted to have similar features including growth failure (75%), microcephaly (70%), and craniofacial abnormalities consisting of ocular hypertelorism (50%); prominent box-like appearance of the forehead (75%); flat nasal bridge (70%); mild upward or downward obliquity of the eyes (65%); long palpebral fissures with blue sclerae (60%); short nose with flattened columella and well-formed, triangular philtrum (65%); and patulous lips (60%). These features constitute a new and distinct dysmorphic syndrome, the HTLV-III embryopathy.

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