Human T-Cell Lymphotropic Virus Type III (HTLV-III) Embryopathy: A New Dysmorphic Syndrome Associated With Intrauterine HTLV-III Infection

Robert W. Marion, R. Gordon Hutcheon, Arye Rubinstein

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Abstract

Twenty infants and children with positive serologic tests for the human T-cell lymphotropic virus type III (HTLV-III) were noted to have similar features including growth failure (75%), microcephaly (70%), and craniofacial abnormalities consisting of ocular hypertelorism (50%); prominent box-like appearance of the forehead (75%); flat nasal bridge (70%); mild upward or downward obliquity of the eyes (65%); long palpebral fissures with blue sclerae (60%); short nose with flattened columella and well-formed, triangular philtrum (65%); and patulous lips (60%). These features constitute a new and distinct dysmorphic syndrome, the HTLV-III embryopathy.

Original languageEnglish (US)
Pages (from-to)638-640
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume140
Issue number7
DOIs
StatePublished - Jul 1986

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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