Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: Implications for a proper understanding of type-specific persistent infections

Long Fu Xi; Laura A. Koutsky; Philip E. Castle; Zoe R. Edelstein; Ayaka Hulbert; Mark Schiffman; Nancy B. Kiviat

doi:10.1086/657083

Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: Implications for a proper understanding of type-specific persistent infections

Long Fu Xi, Laura A. Koutsky, Philip E. Castle, Zoe R. Edelstein, Ayaka Hulbert, Mark Schiffman, Nancy B. Kiviat

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Prospective studies of the persistence of human papillomavirus (HPV) variants are rare and typically small. We sequenced HPV-16 variants in longitudinal pairs of specimens from 86 women enrolled in the ASCUS-LSIL Triage Study. A change of variants was identified in 4 women (4.7% [95% confidence interval, 1.3%-11.5%]). Among women with intervening HPV results (n = 60), a variant switch occurred in 2 of 11 who had evidence of intervening negativity for HPV-16, compared with 1 of 49 who consistently tested positive (P = .11). These results suggest the possibility that rare misclassification of transient infections as persistent infections occurs in natural history studies of type-specific HPV infections.

Original language	English (US)
Pages (from-to)	1667-1670
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	202
Issue number	11
DOIs	https://doi.org/10.1086/657083
State	Published - Dec 1 2010
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/657083

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Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: Implications for a proper understanding of type-specific persistent infections. / Xi, Long Fu; Koutsky, Laura A.; Castle, Philip E. et al.
In: Journal of Infectious Diseases, Vol. 202, No. 11, 01.12.2010, p. 1667-1670.

Research output: Contribution to journal › Article › peer-review

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title = "Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: Implications for a proper understanding of type-specific persistent infections",

abstract = "Prospective studies of the persistence of human papillomavirus (HPV) variants are rare and typically small. We sequenced HPV-16 variants in longitudinal pairs of specimens from 86 women enrolled in the ASCUS-LSIL Triage Study. A change of variants was identified in 4 women (4.7% [95% confidence interval, 1.3%-11.5%]). Among women with intervening HPV results (n = 60), a variant switch occurred in 2 of 11 who had evidence of intervening negativity for HPV-16, compared with 1 of 49 who consistently tested positive (P = .11). These results suggest the possibility that rare misclassification of transient infections as persistent infections occurs in natural history studies of type-specific HPV infections.",

author = "Xi, {Long Fu} and Koutsky, {Laura A.} and Castle, {Philip E.} and Edelstein, {Zoe R.} and Ayaka Hulbert and Mark Schiffman and Kiviat, {Nancy B.}",

note = "Funding Information: Received 7 May 2010; accepted 15 June 2010; electronically published 26 October 2010. Potential conflicts of interest: L.A.K. receives research funds from Merck Research Laboratories. All other authors report no potential conflicts. Financial support: Public Health Service (grant CA133569 to L.F.X.). Reprints or correspondence: Dr Long Fu Xi, University of Washington, Dept of Pathology, Harborview Medical Center, NJB Ste 1187, 325 9th Ave, Seattle, WA 98104 (longfu@u .washington.edu).",

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Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: Implications for a proper understanding of type-specific persistent infections

Abstract

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