Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: Implications for a proper understanding of type-specific persistent infections

Long Fu Xi, Laura A. Koutsky, Philip E. Castle, Zoe R. Edelstein, Ayaka Hulbert, Mark Schiffman, Nancy B. Kiviat

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Prospective studies of the persistence of human papillomavirus (HPV) variants are rare and typically small. We sequenced HPV-16 variants in longitudinal pairs of specimens from 86 women enrolled in the ASCUS-LSIL Triage Study. A change of variants was identified in 4 women (4.7% [95% confidence interval, 1.3%-11.5%]). Among women with intervening HPV results (n = 60), a variant switch occurred in 2 of 11 who had evidence of intervening negativity for HPV-16, compared with 1 of 49 who consistently tested positive (P = .11). These results suggest the possibility that rare misclassification of transient infections as persistent infections occurs in natural history studies of type-specific HPV infections.

Original languageEnglish (US)
Pages (from-to)1667-1670
Number of pages4
JournalJournal of Infectious Diseases
Volume202
Issue number11
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

Human papillomavirus 16
Infection
Papillomavirus Infections
Triage
Natural History
Prospective Studies
Confidence Intervals

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples : Implications for a proper understanding of type-specific persistent infections. / Xi, Long Fu; Koutsky, Laura A.; Castle, Philip E.; Edelstein, Zoe R.; Hulbert, Ayaka; Schiffman, Mark; Kiviat, Nancy B.

In: Journal of Infectious Diseases, Vol. 202, No. 11, 01.12.2010, p. 1667-1670.

Research output: Contribution to journalArticle

Xi, Long Fu ; Koutsky, Laura A. ; Castle, Philip E. ; Edelstein, Zoe R. ; Hulbert, Ayaka ; Schiffman, Mark ; Kiviat, Nancy B. / Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples : Implications for a proper understanding of type-specific persistent infections. In: Journal of Infectious Diseases. 2010 ; Vol. 202, No. 11. pp. 1667-1670.
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