Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: Implications for a proper understanding of type-specific persistent infections

Long Fu Xi, Laura A. Koutsky, Philip E. Castle, Zoe R. Edelstein, Ayaka Hulbert, Mark Schiffman, Nancy B. Kiviat

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Prospective studies of the persistence of human papillomavirus (HPV) variants are rare and typically small. We sequenced HPV-16 variants in longitudinal pairs of specimens from 86 women enrolled in the ASCUS-LSIL Triage Study. A change of variants was identified in 4 women (4.7% [95% confidence interval, 1.3%-11.5%]). Among women with intervening HPV results (n = 60), a variant switch occurred in 2 of 11 who had evidence of intervening negativity for HPV-16, compared with 1 of 49 who consistently tested positive (P = .11). These results suggest the possibility that rare misclassification of transient infections as persistent infections occurs in natural history studies of type-specific HPV infections.

Original languageEnglish (US)
Pages (from-to)1667-1670
Number of pages4
JournalJournal of Infectious Diseases
Volume202
Issue number11
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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