Human Papillomavirus Type 11 Transcripts Are Present at Low Abundance in Latently Infected Respiratory Tissues

A. Maran, C. A. Amella, Teresa P. DiLorenzo, K. J. Auborn, L. B. Taichman, B. M. Steinberg

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Respiratory tract tissues containing latent human papillomavirus (HPV) 11 were analyzed by reverse transcription-polymerase chain reaction for the presence of viral-specific RNA from the early region of the genome and compared to a similar analysis of laryngeal papillomas. Latently infected tissue contained low-abundance transcripts that could code for E1 and E2 proteins, but lacked evidence of spliced transcripts for the E6 and E7 proteins. Both latently infected tissue and papilloma tissue contained low-abundance antisense transcripts. Cultured cells infected with HPV 11 virions or transfected with HPV DNA, and cells derived from latently infected tissue, expressed transcripts similar to those seen in papillomas, but at a lower abundance. We postulate that latency is determined by the absence of or limiting levels of critical viral proteins.

Original languageEnglish (US)
Pages (from-to)285-294
Number of pages10
JournalVirology
Volume212
Issue number2
DOIs
StatePublished - Oct 1 1995

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Human papillomavirus 11
Papilloma
Viral RNA
Viral Proteins
Virion
Respiratory System
Reverse Transcription
Cultured Cells
Proteins
Genome
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Human Papillomavirus Type 11 Transcripts Are Present at Low Abundance in Latently Infected Respiratory Tissues. / Maran, A.; Amella, C. A.; DiLorenzo, Teresa P.; Auborn, K. J.; Taichman, L. B.; Steinberg, B. M.

In: Virology, Vol. 212, No. 2, 01.10.1995, p. 285-294.

Research output: Contribution to journalArticle

Maran, A. ; Amella, C. A. ; DiLorenzo, Teresa P. ; Auborn, K. J. ; Taichman, L. B. ; Steinberg, B. M. / Human Papillomavirus Type 11 Transcripts Are Present at Low Abundance in Latently Infected Respiratory Tissues. In: Virology. 1995 ; Vol. 212, No. 2. pp. 285-294.
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