Human Papillomavirus Type 11 Transcripts Are Present at Low Abundance in Latently Infected Respiratory Tissues

A. Maran, C. A. Amella, T. P. Di Lorenzo, K. J. Auborn, L. B. Taichman, B. M. Steinberg

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Respiratory tract tissues containing latent human papillomavirus (HPV) 11 were analyzed by reverse transcription-polymerase chain reaction for the presence of viral-specific RNA from the early region of the genome and compared to a similar analysis of laryngeal papillomas. Latently infected tissue contained low-abundance transcripts that could code for E1 and E2 proteins, but lacked evidence of spliced transcripts for the E6 and E7 proteins. Both latently infected tissue and papilloma tissue contained low-abundance antisense transcripts. Cultured cells infected with HPV 11 virions or transfected with HPV DNA, and cells derived from latently infected tissue, expressed transcripts similar to those seen in papillomas, but at a lower abundance. We postulate that latency is determined by the absence of or limiting levels of critical viral proteins.

Original languageEnglish (US)
Article number71486
Pages (from-to)285-294
Number of pages10
JournalVirology
Volume212
Issue number2
DOIs
StatePublished - Oct 1 1995

ASJC Scopus subject areas

  • Virology

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