Human papillomavirus genomics

Past, present and future

Ariana Harari, Zigui Chen, Robert D. Burk

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Human papillomaviruses (HPV) are a group of divergent DNA viruses, of which a select few evolutionarily related HPVs have emerged to be highly oncogenic and of significant medical importance. Essentially all cases of cervical cancer, as well as a subset of other anogenital and oral cancers are caused by this limited set of HPV types. At present, over 150 HPV types have been identified and may be classified into genera, species and types based upon comparison of the viral genome. Established nucleotide phylogenies sort the highly pathogenic HPV types to the genus Alphapapillomavirus (α-PV). A species group includes viral types with 60-70% genomic nucleotide similarity that share a most-recent common ancestor; for example the species group's alpha-9 (HPV16-related) and alpha-7 (HPV18-related), contain the majority of known oncogenic HPV types. Genomes from the same HPV type with 1-10% nucleotide differences designate HPV variant lineages. The established nucleotide variations observed in extant HPV genomes have been fixed through evolutionary processes prior to human population expansion and global dissemination. To characterize viral types and variants associated with pathology for clinical applications (e.g. screening), molecular epidemiological studies have proven essential for identifying links between HPV natural history and carcinogenicity. This chapter presents a historical account of HPV genomics in the context of major discoveries and advances over the past 2 thousand years.

Original languageEnglish (US)
Pages (from-to)1-18
Number of pages18
JournalCurrent Problems in Dermatology
Volume45
DOIs
StatePublished - 2014

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Genomics
Nucleotides
Human Genome
Alphapapillomavirus
Clinical Pathology
DNA Viruses
Viral Genome
Mouth Neoplasms
Phylogeny
Natural History
Uterine Cervical Neoplasms
Epidemiologic Studies

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Human papillomavirus genomics : Past, present and future. / Harari, Ariana; Chen, Zigui; Burk, Robert D.

In: Current Problems in Dermatology, Vol. 45, 2014, p. 1-18.

Research output: Contribution to journalArticle

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