Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women

Ruth M. Greenblatt, Lisa P. Jacobson, Alexandra M. Levine, Sandra Melnick, Kathryn Anastos, Mardge Cohen, Jack DeHovitz, Mary A. Young, David Burns, Paolo Miotti, David M. Koelle

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48 Scopus citations

Abstract

Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 infection among human immunodeficiency virus (HIV)-infected and high-risk HIV-uninfected women. Serological tests with noninduced (latent) and induced (lytic) HHV-8 antigens were used to detect infection among 2483 participants of a multisite cohort. Reactivity to latent antigen was present in 4.1% and to induced antigens in 12.0% of women. Seven of 8 women who reported Kaposi's sarcoma had HHV-8 antibodies. Among HIV-positive women, HHV-8 infection was associated with use of crack, cocaine, or heroin (76% vs. 65%; P < .001), past syphilis (29% vs. 20%; P < .001), an injection drug-using male sex partner (61% vs. 53%; P = .014), black race (P = .010), and enrollment site (P = .015). In multivariate analysis, HIV infection, older age, past syphilis, black race, and enrollment site were independently associated with HHV-8 infection. In this cohort of North American women, HHV-8 infection was associated with HIV infection, drug use, and risky sexual behavior.

Original languageEnglish (US)
Pages (from-to)1130-1134
Number of pages5
JournalJournal of Infectious Diseases
Volume183
Issue number7
DOIs
StatePublished - Apr 1 2001

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Greenblatt, R. M., Jacobson, L. P., Levine, A. M., Melnick, S., Anastos, K., Cohen, M., DeHovitz, J., Young, M. A., Burns, D., Miotti, P., & Koelle, D. M. (2001). Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women. Journal of Infectious Diseases, 183(7), 1130-1134. https://doi.org/10.1086/319270