Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women

R. M. Greenblatt, L. P. Jacobson, A. M. Levine, S. Melnick, Kathryn Anastos, M. Cohen, J. DeHovitz, M. A. Young, D. Burns, P. Miotti, D. M. Koelle

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 infection among human immunodeficiency virus (HIV)-infected and high-risk HIV-uninfected women. Serological tests with noninduced (latent) and induced (lytic) HHV-8 antigens were used to detect infection among 2483 participants of a multisite cohort. Reactivity to latent antigen was present in 4.1% and to induced antigens in 12.0% of women. Seven of 8 women who reported Kaposi's sarcoma had HHV-8 antibodies. Among HIV-positive women, HHV-8 infection was associated with use of crack, cocaine, or heroin (76% vs. 65%; P < .001), past syphilis (29% vs. 20%; P < .001), an injection drug-using male sex partner (61% vs. 53%; P = .014), black race (P = .010), and enrollment site (P = .015). In multivariate analysis, HIV infection, older age, past syphilis, black race, and enrollment site were independently associated with HHV-8 infection. In this cohort of North American women, HHV-8 infection was associated with HIV infection, drug use, and risky sexual behavior.

Original languageEnglish (US)
Pages (from-to)1130-1134
Number of pages5
JournalJournal of Infectious Diseases
Volume183
Issue number7
DOIs
StatePublished - Apr 1 2001

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Herpesviridae Infections
Human Herpesvirus 8
Kaposi's Sarcoma
HIV
Virus Diseases
Syphilis
Antigens
Crack Cocaine
Heroin
Serologic Tests
Sexual Behavior
Pharmaceutical Preparations
Epidemiology
Multivariate Analysis
Cross-Sectional Studies
Injections
Antibodies
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women. / Greenblatt, R. M.; Jacobson, L. P.; Levine, A. M.; Melnick, S.; Anastos, Kathryn; Cohen, M.; DeHovitz, J.; Young, M. A.; Burns, D.; Miotti, P.; Koelle, D. M.

In: Journal of Infectious Diseases, Vol. 183, No. 7, 01.04.2001, p. 1130-1134.

Research output: Contribution to journalArticle

Greenblatt, RM, Jacobson, LP, Levine, AM, Melnick, S, Anastos, K, Cohen, M, DeHovitz, J, Young, MA, Burns, D, Miotti, P & Koelle, DM 2001, 'Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women', Journal of Infectious Diseases, vol. 183, no. 7, pp. 1130-1134. https://doi.org/10.1086/319270
Greenblatt, R. M. ; Jacobson, L. P. ; Levine, A. M. ; Melnick, S. ; Anastos, Kathryn ; Cohen, M. ; DeHovitz, J. ; Young, M. A. ; Burns, D. ; Miotti, P. ; Koelle, D. M. / Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women. In: Journal of Infectious Diseases. 2001 ; Vol. 183, No. 7. pp. 1130-1134.
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