Human gouty arthritis is associated with a distinct serum trace elemental profile

Mingming Su, Ting Zhang, Tie Zhao, Fen Li, Yan Ni, Xiaoyan Wang, Tianlu Chen, Aihua Zhao, Yunping Qiu, Yuqian Bao, Weiping Jie, Wei Jia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Homeostatic imbalance of essential trace elements is deeply involved in many pathophysiological states, especially in joint disorders such as gout. A total of 64 elements were measured in the serum samples in three regionally independent groups of patients with gouty arthritis (n = 100) and an age-matched healthy control group (n = 40) by inductively coupled plasma-mass spectrometry (ICP-MS). A distinct elemental profile of gouty arthritis encompassing significantly altered Li, Al, Ti, Fe, Cu, Se, Sr, Ta, Hg, Bi, Th, and U was obtained with a sensitivity of 0.97 (95% confidence interval (CI): 0.92-0.99) and a specificity of 0.95 (95% CI: 0.83-0.99) for gout diagnosis. An independent group of 52 subjects (39 gout patients and 13 healthy controls) was further used to validate the elemental signature, yielding a sensitivity of 1.00 (95% CI: 0.91-1.00) and a specificity of 1.00 (95% CI: 0.75-1.00) for gout prediction. It is also noteworthy that we were able to achieve ≥95.7% correct classification rate in both discovery and validation groups using only three elemental markers, Li, Al, and U. We also observed a good correlation between Li, Zn, and Cu and the other two risk factors, age and serum urate concentration, in gout patients. Our findings underscore that gouty arthritis possesses a unique elemental expression profile regardless of many other nutritional and environmental factors.

Original languageEnglish (US)
Pages (from-to)244-252
Number of pages9
JournalMetallomics
Volume4
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Fingerprint

Gouty Arthritis
Gout
Inductively coupled plasma mass spectrometry
Confidence Intervals
Trace Elements
Uric Acid
Trace elements
Serum
Mass Spectrometry
Joints
Control Groups

ASJC Scopus subject areas

  • Biomaterials
  • Metals and Alloys
  • Chemistry (miscellaneous)
  • Biochemistry
  • Biophysics

Cite this

Su, M., Zhang, T., Zhao, T., Li, F., Ni, Y., Wang, X., ... Jia, W. (2012). Human gouty arthritis is associated with a distinct serum trace elemental profile. Metallomics, 4(3), 244-252. https://doi.org/10.1039/c2mt00178k

Human gouty arthritis is associated with a distinct serum trace elemental profile. / Su, Mingming; Zhang, Ting; Zhao, Tie; Li, Fen; Ni, Yan; Wang, Xiaoyan; Chen, Tianlu; Zhao, Aihua; Qiu, Yunping; Bao, Yuqian; Jie, Weiping; Jia, Wei.

In: Metallomics, Vol. 4, No. 3, 03.2012, p. 244-252.

Research output: Contribution to journalArticle

Su, M, Zhang, T, Zhao, T, Li, F, Ni, Y, Wang, X, Chen, T, Zhao, A, Qiu, Y, Bao, Y, Jie, W & Jia, W 2012, 'Human gouty arthritis is associated with a distinct serum trace elemental profile', Metallomics, vol. 4, no. 3, pp. 244-252. https://doi.org/10.1039/c2mt00178k
Su, Mingming ; Zhang, Ting ; Zhao, Tie ; Li, Fen ; Ni, Yan ; Wang, Xiaoyan ; Chen, Tianlu ; Zhao, Aihua ; Qiu, Yunping ; Bao, Yuqian ; Jie, Weiping ; Jia, Wei. / Human gouty arthritis is associated with a distinct serum trace elemental profile. In: Metallomics. 2012 ; Vol. 4, No. 3. pp. 244-252.
@article{919d61e65fd9485d953f4b036ca5ca34,
title = "Human gouty arthritis is associated with a distinct serum trace elemental profile",
abstract = "Homeostatic imbalance of essential trace elements is deeply involved in many pathophysiological states, especially in joint disorders such as gout. A total of 64 elements were measured in the serum samples in three regionally independent groups of patients with gouty arthritis (n = 100) and an age-matched healthy control group (n = 40) by inductively coupled plasma-mass spectrometry (ICP-MS). A distinct elemental profile of gouty arthritis encompassing significantly altered Li, Al, Ti, Fe, Cu, Se, Sr, Ta, Hg, Bi, Th, and U was obtained with a sensitivity of 0.97 (95{\%} confidence interval (CI): 0.92-0.99) and a specificity of 0.95 (95{\%} CI: 0.83-0.99) for gout diagnosis. An independent group of 52 subjects (39 gout patients and 13 healthy controls) was further used to validate the elemental signature, yielding a sensitivity of 1.00 (95{\%} CI: 0.91-1.00) and a specificity of 1.00 (95{\%} CI: 0.75-1.00) for gout prediction. It is also noteworthy that we were able to achieve ≥95.7{\%} correct classification rate in both discovery and validation groups using only three elemental markers, Li, Al, and U. We also observed a good correlation between Li, Zn, and Cu and the other two risk factors, age and serum urate concentration, in gout patients. Our findings underscore that gouty arthritis possesses a unique elemental expression profile regardless of many other nutritional and environmental factors.",
author = "Mingming Su and Ting Zhang and Tie Zhao and Fen Li and Yan Ni and Xiaoyan Wang and Tianlu Chen and Aihua Zhao and Yunping Qiu and Yuqian Bao and Weiping Jie and Wei Jia",
year = "2012",
month = "3",
doi = "10.1039/c2mt00178k",
language = "English (US)",
volume = "4",
pages = "244--252",
journal = "Metallomics",
issn = "1756-5901",
publisher = "Royal Society of Chemistry",
number = "3",

}

TY - JOUR

T1 - Human gouty arthritis is associated with a distinct serum trace elemental profile

AU - Su, Mingming

AU - Zhang, Ting

AU - Zhao, Tie

AU - Li, Fen

AU - Ni, Yan

AU - Wang, Xiaoyan

AU - Chen, Tianlu

AU - Zhao, Aihua

AU - Qiu, Yunping

AU - Bao, Yuqian

AU - Jie, Weiping

AU - Jia, Wei

PY - 2012/3

Y1 - 2012/3

N2 - Homeostatic imbalance of essential trace elements is deeply involved in many pathophysiological states, especially in joint disorders such as gout. A total of 64 elements were measured in the serum samples in three regionally independent groups of patients with gouty arthritis (n = 100) and an age-matched healthy control group (n = 40) by inductively coupled plasma-mass spectrometry (ICP-MS). A distinct elemental profile of gouty arthritis encompassing significantly altered Li, Al, Ti, Fe, Cu, Se, Sr, Ta, Hg, Bi, Th, and U was obtained with a sensitivity of 0.97 (95% confidence interval (CI): 0.92-0.99) and a specificity of 0.95 (95% CI: 0.83-0.99) for gout diagnosis. An independent group of 52 subjects (39 gout patients and 13 healthy controls) was further used to validate the elemental signature, yielding a sensitivity of 1.00 (95% CI: 0.91-1.00) and a specificity of 1.00 (95% CI: 0.75-1.00) for gout prediction. It is also noteworthy that we were able to achieve ≥95.7% correct classification rate in both discovery and validation groups using only three elemental markers, Li, Al, and U. We also observed a good correlation between Li, Zn, and Cu and the other two risk factors, age and serum urate concentration, in gout patients. Our findings underscore that gouty arthritis possesses a unique elemental expression profile regardless of many other nutritional and environmental factors.

AB - Homeostatic imbalance of essential trace elements is deeply involved in many pathophysiological states, especially in joint disorders such as gout. A total of 64 elements were measured in the serum samples in three regionally independent groups of patients with gouty arthritis (n = 100) and an age-matched healthy control group (n = 40) by inductively coupled plasma-mass spectrometry (ICP-MS). A distinct elemental profile of gouty arthritis encompassing significantly altered Li, Al, Ti, Fe, Cu, Se, Sr, Ta, Hg, Bi, Th, and U was obtained with a sensitivity of 0.97 (95% confidence interval (CI): 0.92-0.99) and a specificity of 0.95 (95% CI: 0.83-0.99) for gout diagnosis. An independent group of 52 subjects (39 gout patients and 13 healthy controls) was further used to validate the elemental signature, yielding a sensitivity of 1.00 (95% CI: 0.91-1.00) and a specificity of 1.00 (95% CI: 0.75-1.00) for gout prediction. It is also noteworthy that we were able to achieve ≥95.7% correct classification rate in both discovery and validation groups using only three elemental markers, Li, Al, and U. We also observed a good correlation between Li, Zn, and Cu and the other two risk factors, age and serum urate concentration, in gout patients. Our findings underscore that gouty arthritis possesses a unique elemental expression profile regardless of many other nutritional and environmental factors.

UR - http://www.scopus.com/inward/record.url?scp=84863273758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863273758&partnerID=8YFLogxK

U2 - 10.1039/c2mt00178k

DO - 10.1039/c2mt00178k

M3 - Article

VL - 4

SP - 244

EP - 252

JO - Metallomics

JF - Metallomics

SN - 1756-5901

IS - 3

ER -