Human gouty arthritis is associated with a distinct serum trace elemental profile

Mingming Su, Ting Zhang, Tie Zhao, Fen Li, Yan Ni, Xiaoyan Wang, Tianlu Chen, Aihua Zhao, Yunping Qiu, Yuqian Bao, Weiping Jie, Wei Jia

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Homeostatic imbalance of essential trace elements is deeply involved in many pathophysiological states, especially in joint disorders such as gout. A total of 64 elements were measured in the serum samples in three regionally independent groups of patients with gouty arthritis (n = 100) and an age-matched healthy control group (n = 40) by inductively coupled plasma-mass spectrometry (ICP-MS). A distinct elemental profile of gouty arthritis encompassing significantly altered Li, Al, Ti, Fe, Cu, Se, Sr, Ta, Hg, Bi, Th, and U was obtained with a sensitivity of 0.97 (95% confidence interval (CI): 0.92-0.99) and a specificity of 0.95 (95% CI: 0.83-0.99) for gout diagnosis. An independent group of 52 subjects (39 gout patients and 13 healthy controls) was further used to validate the elemental signature, yielding a sensitivity of 1.00 (95% CI: 0.91-1.00) and a specificity of 1.00 (95% CI: 0.75-1.00) for gout prediction. It is also noteworthy that we were able to achieve ≥95.7% correct classification rate in both discovery and validation groups using only three elemental markers, Li, Al, and U. We also observed a good correlation between Li, Zn, and Cu and the other two risk factors, age and serum urate concentration, in gout patients. Our findings underscore that gouty arthritis possesses a unique elemental expression profile regardless of many other nutritional and environmental factors.

Original languageEnglish (US)
Pages (from-to)244-252
Number of pages9
JournalMetallomics
Volume4
Issue number3
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Biophysics
  • Biomaterials
  • Biochemistry
  • Metals and Alloys

Cite this

Su, M., Zhang, T., Zhao, T., Li, F., Ni, Y., Wang, X., Chen, T., Zhao, A., Qiu, Y., Bao, Y., Jie, W., & Jia, W. (2012). Human gouty arthritis is associated with a distinct serum trace elemental profile. Metallomics, 4(3), 244-252. https://doi.org/10.1039/c2mt00178k