huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding

Q. Chu-LaGraff, A. Schmid, J. Leidel, G. Brönner, H. Jäckle, C. Q. Doe

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

huckebein encodes a putative zinc finger protein expressed in a subset of Drosophila CNS precursors, including the NB 4-2/GMC 4-2a/RP2 cell lineage. Inhuckebein mutant embryos, GMC 4-2a does not express the cell fate marker EVEN-SKIPPED; conversely,huckebein overexpression produces a duplicate EVEN-SKIPPED-positive GMC 4-2a. We use Dil to trace the entire NB 4-2 lineage in wild-type andhuckebein mutant embryos. Loss ofhuckebein does not affect the number, position, or type of neurons in the NB 4-2 lineage; however, all motoneurons show axon pathfinding defects and never terminate at the correct muscle. Thus,huckebein regulates aspects of GMC and neuronal identity required for proper motoneuron axon pathfinding in the NB 4-2 lineage.

Original languageEnglish (US)
Pages (from-to)1041-1051
Number of pages11
JournalNeuron
Volume15
Issue number5
DOIs
StatePublished - Nov 1995

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding'. Together they form a unique fingerprint.

  • Cite this

    Chu-LaGraff, Q., Schmid, A., Leidel, J., Brönner, G., Jäckle, H., & Doe, C. Q. (1995). huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding. Neuron, 15(5), 1041-1051. https://doi.org/10.1016/0896-6273(95)90093-4