huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding

Q. Chu-LaGraff, A. Schmid, Jennifer L. Liedel, G. Brönner, H. Jäckle, C. Q. Doe

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

huckebein encodes a putative zinc finger protein expressed in a subset of Drosophila CNS precursors, including the NB 4-2/GMC 4-2a/RP2 cell lineage. Inhuckebein mutant embryos, GMC 4-2a does not express the cell fate marker EVEN-SKIPPED; conversely,huckebein overexpression produces a duplicate EVEN-SKIPPED-positive GMC 4-2a. We use Dil to trace the entire NB 4-2 lineage in wild-type andhuckebein mutant embryos. Loss ofhuckebein does not affect the number, position, or type of neurons in the NB 4-2 lineage; however, all motoneurons show axon pathfinding defects and never terminate at the correct muscle. Thus,huckebein regulates aspects of GMC and neuronal identity required for proper motoneuron axon pathfinding in the NB 4-2 lineage.

Original languageEnglish (US)
Pages (from-to)1041-1051
Number of pages11
JournalNeuron
Volume15
Issue number5
DOIs
StatePublished - 1995
Externally publishedYes

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Motor Neurons
Embryonic Structures
Zinc Fingers
Cell Lineage
Drosophila
Neurons
Muscles
Proteins
Axon Guidance

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chu-LaGraff, Q., Schmid, A., Liedel, J. L., Brönner, G., Jäckle, H., & Doe, C. Q. (1995). huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding. Neuron, 15(5), 1041-1051. https://doi.org/10.1016/0896-6273(95)90093-4

huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding. / Chu-LaGraff, Q.; Schmid, A.; Liedel, Jennifer L.; Brönner, G.; Jäckle, H.; Doe, C. Q.

In: Neuron, Vol. 15, No. 5, 1995, p. 1041-1051.

Research output: Contribution to journalArticle

Chu-LaGraff, Q, Schmid, A, Liedel, JL, Brönner, G, Jäckle, H & Doe, CQ 1995, 'huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding', Neuron, vol. 15, no. 5, pp. 1041-1051. https://doi.org/10.1016/0896-6273(95)90093-4
Chu-LaGraff, Q. ; Schmid, A. ; Liedel, Jennifer L. ; Brönner, G. ; Jäckle, H. ; Doe, C. Q. / huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding. In: Neuron. 1995 ; Vol. 15, No. 5. pp. 1041-1051.
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