Host immunity to Cryptococcus neoformans

Soma Rohatgi, Liise Anne Pirofski

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Cryptococcosis is caused by the fungal genus Cryptococcus. Cryptococcosis, predominantly meningoencephalitis, emerged with the HIV pandemic, primarily afflicting HIV-infected patients with profound T-cell deficiency. Where in use, combination antiretroviral therapy has markedly reduced the incidence of and risk for disease, but cryptococcosis continues to afflict those without access to therapy, particularly in sub-Saharan Africa and Asia. However, cryptococcosis also occurs in solid organ transplant recipients and patients with other immunodeficiencies as well as those with no known immunodeficiency. This article reviews innate and adaptive immune responses to C. neoformans, with an emphasis on recent studies on the role of B cells, natural IgM and Fc gamma receptor polymorphisms in resistance to cryptococcosis.

Original languageEnglish (US)
Pages (from-to)565-581
Number of pages17
JournalFuture Microbiology
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2015

    Fingerprint

Keywords

  • B cells
  • Cryptococcus neoformans
  • Fc receptors
  • T cells
  • acquired immunity
  • antibodies
  • cryptococcosis
  • host response
  • innate immunity
  • macrophages
  • polymorphism

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this