Host immunity to Cryptococcus neoformans

Soma Rohatgi, Liise-anne Pirofski

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Cryptococcosis is caused by the fungal genus Cryptococcus. Cryptococcosis, predominantly meningoencephalitis, emerged with the HIV pandemic, primarily afflicting HIV-infected patients with profound T-cell deficiency. Where in use, combination antiretroviral therapy has markedly reduced the incidence of and risk for disease, but cryptococcosis continues to afflict those without access to therapy, particularly in sub-Saharan Africa and Asia. However, cryptococcosis also occurs in solid organ transplant recipients and patients with other immunodeficiencies as well as those with no known immunodeficiency. This article reviews innate and adaptive immune responses to C. neoformans, with an emphasis on recent studies on the role of B cells, natural IgM and Fc gamma receptor polymorphisms in resistance to cryptococcosis.

Original languageEnglish (US)
Pages (from-to)565-581
Number of pages17
JournalFuture Microbiology
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Cryptococcosis
Cryptococcus neoformans
Immunity
HIV
IgG Receptors
Cryptococcus
Meningoencephalitis
Africa South of the Sahara
Adaptive Immunity
Pandemics
Innate Immunity
B-Lymphocytes
T-Lymphocytes
Transplants
Incidence
Therapeutics

Keywords

  • acquired immunity
  • antibodies
  • B cells
  • cryptococcosis
  • Cryptococcus neoformans
  • Fc receptors
  • host response
  • innate immunity
  • macrophages
  • polymorphism
  • T cells

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Host immunity to Cryptococcus neoformans. / Rohatgi, Soma; Pirofski, Liise-anne.

In: Future Microbiology, Vol. 10, No. 4, 01.04.2015, p. 565-581.

Research output: Contribution to journalArticle

Rohatgi, Soma ; Pirofski, Liise-anne. / Host immunity to Cryptococcus neoformans. In: Future Microbiology. 2015 ; Vol. 10, No. 4. pp. 565-581.
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