Hormone replacement therapy in postmenopausal women with schizophrenia

Positive effect on negative symptoms?

L. A. Lindamer, D. C. Buse, J. B. Lohr, D. V. Jeste

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Background: Some studies of premenopausal women suggest that the severity of psychopathology associated with schizophrenia may be related to levels of estrogen. Methods: We examined psychopathology in community-dwelling postmenopausal women with schizophrenia who had received (n = 24) versus had never received (n = 28) hormone replacement therapy. Results: Users of hormone replacement therapy and nonusers did not differ significantly with respect to age, ethnicity, education, age of onset, duration of schizophrenia, global cognitive functioning, or neuroleptic-induced movement disorders. The hormone replacement therapy users received lower average daily doses of antipsychotic medication; they had similar levels of positive symptoms but significantly less severe negative symptoms compared with hormone replacement therapy nonusers, independent of differences in antipsychotic dosage. Conclusions: Our results suggest that the use of hormone replacement therapy in conjunction with antipsychotic medication in postmenopausal women with schizophrenia may help reduce negative, but not positive, symptoms.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalBiological Psychiatry
Volume49
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Estrogen Replacement Therapy
Hormone Replacement Therapy
Schizophrenia
Antipsychotic Agents
Psychopathology
Independent Living
Movement Disorders
Age of Onset
Estrogens
Education

Keywords

  • Aging
  • Antipsychotics
  • Estrogen
  • Positive and negative symptoms
  • Psychosis

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Hormone replacement therapy in postmenopausal women with schizophrenia : Positive effect on negative symptoms? / Lindamer, L. A.; Buse, D. C.; Lohr, J. B.; Jeste, D. V.

In: Biological Psychiatry, Vol. 49, No. 1, 01.01.2001, p. 47-51.

Research output: Contribution to journalArticle

Lindamer, L. A. ; Buse, D. C. ; Lohr, J. B. ; Jeste, D. V. / Hormone replacement therapy in postmenopausal women with schizophrenia : Positive effect on negative symptoms?. In: Biological Psychiatry. 2001 ; Vol. 49, No. 1. pp. 47-51.
@article{36d736407a6541a091a2c82a7c9e7928,
title = "Hormone replacement therapy in postmenopausal women with schizophrenia: Positive effect on negative symptoms?",
abstract = "Background: Some studies of premenopausal women suggest that the severity of psychopathology associated with schizophrenia may be related to levels of estrogen. Methods: We examined psychopathology in community-dwelling postmenopausal women with schizophrenia who had received (n = 24) versus had never received (n = 28) hormone replacement therapy. Results: Users of hormone replacement therapy and nonusers did not differ significantly with respect to age, ethnicity, education, age of onset, duration of schizophrenia, global cognitive functioning, or neuroleptic-induced movement disorders. The hormone replacement therapy users received lower average daily doses of antipsychotic medication; they had similar levels of positive symptoms but significantly less severe negative symptoms compared with hormone replacement therapy nonusers, independent of differences in antipsychotic dosage. Conclusions: Our results suggest that the use of hormone replacement therapy in conjunction with antipsychotic medication in postmenopausal women with schizophrenia may help reduce negative, but not positive, symptoms.",
keywords = "Aging, Antipsychotics, Estrogen, Positive and negative symptoms, Psychosis",
author = "Lindamer, {L. A.} and Buse, {D. C.} and Lohr, {J. B.} and Jeste, {D. V.}",
year = "2001",
month = "1",
day = "1",
doi = "10.1016/S0006-3223(00)00995-1",
language = "English (US)",
volume = "49",
pages = "47--51",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "1",

}

TY - JOUR

T1 - Hormone replacement therapy in postmenopausal women with schizophrenia

T2 - Positive effect on negative symptoms?

AU - Lindamer, L. A.

AU - Buse, D. C.

AU - Lohr, J. B.

AU - Jeste, D. V.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Background: Some studies of premenopausal women suggest that the severity of psychopathology associated with schizophrenia may be related to levels of estrogen. Methods: We examined psychopathology in community-dwelling postmenopausal women with schizophrenia who had received (n = 24) versus had never received (n = 28) hormone replacement therapy. Results: Users of hormone replacement therapy and nonusers did not differ significantly with respect to age, ethnicity, education, age of onset, duration of schizophrenia, global cognitive functioning, or neuroleptic-induced movement disorders. The hormone replacement therapy users received lower average daily doses of antipsychotic medication; they had similar levels of positive symptoms but significantly less severe negative symptoms compared with hormone replacement therapy nonusers, independent of differences in antipsychotic dosage. Conclusions: Our results suggest that the use of hormone replacement therapy in conjunction with antipsychotic medication in postmenopausal women with schizophrenia may help reduce negative, but not positive, symptoms.

AB - Background: Some studies of premenopausal women suggest that the severity of psychopathology associated with schizophrenia may be related to levels of estrogen. Methods: We examined psychopathology in community-dwelling postmenopausal women with schizophrenia who had received (n = 24) versus had never received (n = 28) hormone replacement therapy. Results: Users of hormone replacement therapy and nonusers did not differ significantly with respect to age, ethnicity, education, age of onset, duration of schizophrenia, global cognitive functioning, or neuroleptic-induced movement disorders. The hormone replacement therapy users received lower average daily doses of antipsychotic medication; they had similar levels of positive symptoms but significantly less severe negative symptoms compared with hormone replacement therapy nonusers, independent of differences in antipsychotic dosage. Conclusions: Our results suggest that the use of hormone replacement therapy in conjunction with antipsychotic medication in postmenopausal women with schizophrenia may help reduce negative, but not positive, symptoms.

KW - Aging

KW - Antipsychotics

KW - Estrogen

KW - Positive and negative symptoms

KW - Psychosis

UR - http://www.scopus.com/inward/record.url?scp=0035054491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035054491&partnerID=8YFLogxK

U2 - 10.1016/S0006-3223(00)00995-1

DO - 10.1016/S0006-3223(00)00995-1

M3 - Article

VL - 49

SP - 47

EP - 51

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 1

ER -