Honey as a Treatment in Otorhinolaryngology: A Review by Subspecialty

Theresa Tharakan, John P. Bent, Raluca Tavaluc

Research output: Contribution to journalReview article

Abstract

Objectives: To provide an up-to-date review of honey’s effectiveness and potential applications in otorhinolaryngology. Methods: A literature search of the online databases PubMed, EMBASE, and Cochrane Central Register of Controlled Trials was conducted. Results: Sixty-three studies were identified within head and neck surgery (n = 23, 36%); pediatric otolaryngology (n = 18, 29%); rhinology, sinus, and skull base surgery (n = 11, 17%); otology (n = 6, 10%), facial plastic and reconstructive surgery (n = 3, 5%); and laryngology (n = 2, 3%). Studies included 6 meta-analyses, 44 randomized control trials, 5 case reports, and 8 animal models or in vitro studies. Of 55 clinical studies, 50 reported Level 1 evidence (prospective randomized control trials), and 5 reported Level 4 evidence (case series). The evidence level by subspecialty was: head and neck surgery (Level 1 n = 23), pediatrics (Level 1 n = 18), rhinology (Level 1 n = 7, level 4 n = 1), otology (Level 1 n = 1, Level 4 n = 3), facial plastics and reconstructive surgery (Level 4 n = 1), and laryngology (Level 1 n = 2). Conclusions: Honey can be used for a variety of otolaryngology conditions. The highest quality meta-analyses support oral honey for prevention and treatment of oral mucositis in cancer patients, cough associated with upper respiratory infection in children, and pain control after tonsillectomy. Further research will likely justify broader applications.

Original languageEnglish (US)
Pages (from-to)193-207
Number of pages15
JournalAnnals of Otology, Rhinology and Laryngology
Volume128
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Honey
Otolaryngology
Reconstructive Surgical Procedures
Plastic Surgery
Meta-Analysis
Neck
Head
Pediatrics
Stomatitis
Tonsillectomy
Skull Base
Cough
PubMed
Respiratory Tract Infections
Animal Models
Databases
Pain
Research
Neoplasms

Keywords

  • complementary therapies
  • evidence-based medicine
  • honey
  • otolaryngology
  • treatment outcomes

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Honey as a Treatment in Otorhinolaryngology : A Review by Subspecialty. / Tharakan, Theresa; Bent, John P.; Tavaluc, Raluca.

In: Annals of Otology, Rhinology and Laryngology, Vol. 128, No. 3, 01.03.2019, p. 193-207.

Research output: Contribution to journalReview article

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abstract = "Objectives: To provide an up-to-date review of honey’s effectiveness and potential applications in otorhinolaryngology. Methods: A literature search of the online databases PubMed, EMBASE, and Cochrane Central Register of Controlled Trials was conducted. Results: Sixty-three studies were identified within head and neck surgery (n = 23, 36{\%}); pediatric otolaryngology (n = 18, 29{\%}); rhinology, sinus, and skull base surgery (n = 11, 17{\%}); otology (n = 6, 10{\%}), facial plastic and reconstructive surgery (n = 3, 5{\%}); and laryngology (n = 2, 3{\%}). Studies included 6 meta-analyses, 44 randomized control trials, 5 case reports, and 8 animal models or in vitro studies. Of 55 clinical studies, 50 reported Level 1 evidence (prospective randomized control trials), and 5 reported Level 4 evidence (case series). The evidence level by subspecialty was: head and neck surgery (Level 1 n = 23), pediatrics (Level 1 n = 18), rhinology (Level 1 n = 7, level 4 n = 1), otology (Level 1 n = 1, Level 4 n = 3), facial plastics and reconstructive surgery (Level 4 n = 1), and laryngology (Level 1 n = 2). Conclusions: Honey can be used for a variety of otolaryngology conditions. The highest quality meta-analyses support oral honey for prevention and treatment of oral mucositis in cancer patients, cough associated with upper respiratory infection in children, and pain control after tonsillectomy. Further research will likely justify broader applications.",
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