HLA-B*07 is a high risk allele for familial cervical cancer

Xiaoping Qiu, Fan Zhang, Dangxiao Chen, Abul Kalam Azad, Li Zhang, Yulin Yuan, Zhongqing Jiang, Wenhui Liu, Yun Tan, Ning Tao

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Aim: The purpose of this study was to investigate 50 women from eight families with familial cervical cancer in Wufeng County, Hubei Province, China, a region with a high incidence of cervical cancer. Eighty-nine healthy women, of similar age, location and ethnicity, were selected as a control group. Methods: Blood samples were collected from both groups, and HLA-A, HLA-B, and HLA-DRB1 genotypes were profiled with the Multi-Analyte Profiling system (xMAP) (Luminex HLA-SSO) using a WAKFlow HLA typing kit. Results were analyzed with Luminex HLA typing software and showed good stability, reproducibility and specificity. Results: We found several high risk alleles in women with familial cervical cancer, that associated with the highest risk being HLA-B*07 (OR = 8.7, 95% CI = 1.8-41.1). Conclusions: HLA-B*07 is a high risk allele for cervical cancer, and has strong potential for use as a molecular biomarker.

Original languageEnglish (US)
Pages (from-to)2597-2600
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume12
Issue number10
StatePublished - 2011
Externally publishedYes

Keywords

  • Allele
  • Cervical cancer
  • Familial risk
  • Haplotype
  • HLA

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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