HIV Infection Is Associated With Abnormal Bone Microarchitecture

Measurement of Trabecular Bone Score in the Women's Interagency HIV Study

Anjali Sharma, Yifei Ma, Phyllis C. Tien, Rebecca Scherzer, Kathryn Anastos, Mardge H. Cohen, Didier Hans, Michael T. Yin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVES: We compared skeletal microarchitecture using trabecular bone score (TBS) and evaluated relationships between change in TBS and lumbar spine (LS) bone mineral density (BMD) in women with and without HIV. METHODS: Dual-energy X-ray absorptiometry was performed on 319 women with HIV and 118 without HIV in the Women's Interagency HIV Study at baseline and 2 and 5 years, to measure regional BMD and lean and fat mass. TBS was extracted from LS dual-energy X-ray absorptiometry images and examined continuously and categorically [normal (≥1.35), intermediate (1.20-1.35), or degraded (≤1.20) microarchitecture]. Pearson correlation and linear regression examined associations of TBS with regional BMD at baseline and over time. RESULTS: Women with HIV were older (43 vs. 37 years), more likely to be postmenopausal (27% vs. 4%), have lower baseline total fat mass, trunk fat, and leg fat than uninfected women, degraded microarchitecture (27% vs. 9%, P = 0.001), and lower baseline mean TBS (1.3 ± 0.1 vs. 1.4 ± 0.1, P < 0.001). After adjusting for age, race, menopause status, and body mass index, TBS remained lower in women with HIV (P < 0.0001). Annual change in TBS correlated with LS BMD change among women with HIV (r = 0.36, P < 0.0001) and without HIV (r = 0.26, P = 0.02); however, mean % annual TBS change did not differ by HIV status (-1.0%/yr ± 2.9% for HIV+ vs. -0.8%/yr ± 1.7% for HIV-, P = 0.42). CONCLUSIONS: Women with HIV have worse bone microarchitecture than uninfected women, but annual percent change in LS BMD or TBS was similar. Use of TBS as an adjunct to BMD to improve prediction of fragility fractures in women with HIV merits further study.

Original languageEnglish (US)
Pages (from-to)441-449
Number of pages9
JournalJournal of acquired immune deficiency syndromes (1999)
Volume78
Issue number4
DOIs
StatePublished - Aug 1 2018

Fingerprint

HIV Infections
HIV
Bone and Bones
Bone Density
Spine
Fats
Photon Absorptiometry
Cancellous Bone
Menopause
Linear Models
Leg
Body Mass Index

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

HIV Infection Is Associated With Abnormal Bone Microarchitecture : Measurement of Trabecular Bone Score in the Women's Interagency HIV Study. / Sharma, Anjali; Ma, Yifei; Tien, Phyllis C.; Scherzer, Rebecca; Anastos, Kathryn; Cohen, Mardge H.; Hans, Didier; Yin, Michael T.

In: Journal of acquired immune deficiency syndromes (1999), Vol. 78, No. 4, 01.08.2018, p. 441-449.

Research output: Contribution to journalArticle

@article{1bc3de5d91b843e2b4d7b52891d4be63,
title = "HIV Infection Is Associated With Abnormal Bone Microarchitecture: Measurement of Trabecular Bone Score in the Women's Interagency HIV Study",
abstract = "OBJECTIVES: We compared skeletal microarchitecture using trabecular bone score (TBS) and evaluated relationships between change in TBS and lumbar spine (LS) bone mineral density (BMD) in women with and without HIV. METHODS: Dual-energy X-ray absorptiometry was performed on 319 women with HIV and 118 without HIV in the Women's Interagency HIV Study at baseline and 2 and 5 years, to measure regional BMD and lean and fat mass. TBS was extracted from LS dual-energy X-ray absorptiometry images and examined continuously and categorically [normal (≥1.35), intermediate (1.20-1.35), or degraded (≤1.20) microarchitecture]. Pearson correlation and linear regression examined associations of TBS with regional BMD at baseline and over time. RESULTS: Women with HIV were older (43 vs. 37 years), more likely to be postmenopausal (27{\%} vs. 4{\%}), have lower baseline total fat mass, trunk fat, and leg fat than uninfected women, degraded microarchitecture (27{\%} vs. 9{\%}, P = 0.001), and lower baseline mean TBS (1.3 ± 0.1 vs. 1.4 ± 0.1, P < 0.001). After adjusting for age, race, menopause status, and body mass index, TBS remained lower in women with HIV (P < 0.0001). Annual change in TBS correlated with LS BMD change among women with HIV (r = 0.36, P < 0.0001) and without HIV (r = 0.26, P = 0.02); however, mean {\%} annual TBS change did not differ by HIV status (-1.0{\%}/yr ± 2.9{\%} for HIV+ vs. -0.8{\%}/yr ± 1.7{\%} for HIV-, P = 0.42). CONCLUSIONS: Women with HIV have worse bone microarchitecture than uninfected women, but annual percent change in LS BMD or TBS was similar. Use of TBS as an adjunct to BMD to improve prediction of fragility fractures in women with HIV merits further study.",
author = "Anjali Sharma and Yifei Ma and Tien, {Phyllis C.} and Rebecca Scherzer and Kathryn Anastos and Cohen, {Mardge H.} and Didier Hans and Yin, {Michael T.}",
year = "2018",
month = "8",
day = "1",
doi = "10.1097/QAI.0000000000001692",
language = "English (US)",
volume = "78",
pages = "441--449",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - HIV Infection Is Associated With Abnormal Bone Microarchitecture

T2 - Measurement of Trabecular Bone Score in the Women's Interagency HIV Study

AU - Sharma, Anjali

AU - Ma, Yifei

AU - Tien, Phyllis C.

AU - Scherzer, Rebecca

AU - Anastos, Kathryn

AU - Cohen, Mardge H.

AU - Hans, Didier

AU - Yin, Michael T.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - OBJECTIVES: We compared skeletal microarchitecture using trabecular bone score (TBS) and evaluated relationships between change in TBS and lumbar spine (LS) bone mineral density (BMD) in women with and without HIV. METHODS: Dual-energy X-ray absorptiometry was performed on 319 women with HIV and 118 without HIV in the Women's Interagency HIV Study at baseline and 2 and 5 years, to measure regional BMD and lean and fat mass. TBS was extracted from LS dual-energy X-ray absorptiometry images and examined continuously and categorically [normal (≥1.35), intermediate (1.20-1.35), or degraded (≤1.20) microarchitecture]. Pearson correlation and linear regression examined associations of TBS with regional BMD at baseline and over time. RESULTS: Women with HIV were older (43 vs. 37 years), more likely to be postmenopausal (27% vs. 4%), have lower baseline total fat mass, trunk fat, and leg fat than uninfected women, degraded microarchitecture (27% vs. 9%, P = 0.001), and lower baseline mean TBS (1.3 ± 0.1 vs. 1.4 ± 0.1, P < 0.001). After adjusting for age, race, menopause status, and body mass index, TBS remained lower in women with HIV (P < 0.0001). Annual change in TBS correlated with LS BMD change among women with HIV (r = 0.36, P < 0.0001) and without HIV (r = 0.26, P = 0.02); however, mean % annual TBS change did not differ by HIV status (-1.0%/yr ± 2.9% for HIV+ vs. -0.8%/yr ± 1.7% for HIV-, P = 0.42). CONCLUSIONS: Women with HIV have worse bone microarchitecture than uninfected women, but annual percent change in LS BMD or TBS was similar. Use of TBS as an adjunct to BMD to improve prediction of fragility fractures in women with HIV merits further study.

AB - OBJECTIVES: We compared skeletal microarchitecture using trabecular bone score (TBS) and evaluated relationships between change in TBS and lumbar spine (LS) bone mineral density (BMD) in women with and without HIV. METHODS: Dual-energy X-ray absorptiometry was performed on 319 women with HIV and 118 without HIV in the Women's Interagency HIV Study at baseline and 2 and 5 years, to measure regional BMD and lean and fat mass. TBS was extracted from LS dual-energy X-ray absorptiometry images and examined continuously and categorically [normal (≥1.35), intermediate (1.20-1.35), or degraded (≤1.20) microarchitecture]. Pearson correlation and linear regression examined associations of TBS with regional BMD at baseline and over time. RESULTS: Women with HIV were older (43 vs. 37 years), more likely to be postmenopausal (27% vs. 4%), have lower baseline total fat mass, trunk fat, and leg fat than uninfected women, degraded microarchitecture (27% vs. 9%, P = 0.001), and lower baseline mean TBS (1.3 ± 0.1 vs. 1.4 ± 0.1, P < 0.001). After adjusting for age, race, menopause status, and body mass index, TBS remained lower in women with HIV (P < 0.0001). Annual change in TBS correlated with LS BMD change among women with HIV (r = 0.36, P < 0.0001) and without HIV (r = 0.26, P = 0.02); however, mean % annual TBS change did not differ by HIV status (-1.0%/yr ± 2.9% for HIV+ vs. -0.8%/yr ± 1.7% for HIV-, P = 0.42). CONCLUSIONS: Women with HIV have worse bone microarchitecture than uninfected women, but annual percent change in LS BMD or TBS was similar. Use of TBS as an adjunct to BMD to improve prediction of fragility fractures in women with HIV merits further study.

UR - http://www.scopus.com/inward/record.url?scp=85063345997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063345997&partnerID=8YFLogxK

U2 - 10.1097/QAI.0000000000001692

DO - 10.1097/QAI.0000000000001692

M3 - Article

VL - 78

SP - 441

EP - 449

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 4

ER -