HIV infection and prevention of mother-tochild transmission in childbearing women

La romana, Dominican republic, 2002-2006

José Román-Poueriet, Aracelis D. Fernandez, Consuelo M. Beck-Sagué, René García Szabó, Fermin Mercedes, William Duke, Anny Martinez, Stephen Nicholas

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives. To strengthen prevention of mother-to-child HIV transmission (pMTCT) program implementation in La Romana (LR) province, by estimating HIV prevalence and identifying characteristics associated with HIV infection in parturients. Methods. Umbilical cord blood samples were collected at seven obstetrical sites where over 95% of LR's deliveries occur during four phases (pilot, expanded pilot, full study, and pMTCT program monitoring) from 2 August 2002 to 30 September 2006. Results were linked to data abstracted from delivery records. Results. HIV seroprevalence was 2.6% (263/10 040 overall; 114/4 452, full-study phase (95% confidence interval = 2.1%-3.1%)). Most HIV-infected parturients were Dominican (68.9%) and urban (64.0%). However, prevalence was higher among Haitians (3.7%) than Dominicans (2.3% (p < 0.001)), especially those aged 21-25 years (5.2% vs. 2.3% (p < 0.001)), and among rural, batey, and peri-urban (vs. urban) parturients (3.4% vs. 2.3%, (p = 0.003)). HIV prevalence was associated with commercial sex work (reported by only 0.4%), and prior pregnancy. In logistic regression analysis, commercial sex work, Haitian nationality, and prior pregnancy were independently associated with HIV infection. Caesarean deliveries were more frequent, and rose in the last years of the study, among HIV seropositives; however, most deliveries among seropositives (57.5%) were vaginal. Conclusions. HIV prevalence among LR parturients was higher than the estimated prevalence in the Dominican Republic (0.8%-1.0%) and, in contrast to past studies, predominantly affected urban Dominicans. HIV prevalence among LR Haitian parturients was higher than among Dominican counterparts and prenatal clinic attendees in Haiti (who had a rate of 3.1%). Consistently implemented, targeted pMTCT interventions are needed.

Original languageEnglish (US)
Pages (from-to)315-323
Number of pages9
JournalRevista Panamericana de Salud Publica/Pan American Journal of Public Health
Volume26
Issue number4
StatePublished - Oct 2009
Externally publishedYes

Fingerprint

Dominican Republic
HIV Infections
Mothers
HIV
Parturition
Sex Work
HIV Seroprevalence
Haiti
Pregnancy
Fetal Blood
Ethnic Groups
Logistic Models
Regression Analysis
Confidence Intervals

Keywords

  • Dominican Republic
  • Hiv infections
  • Infectious disease transmission, vertical

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Román-Poueriet, J., Fernandez, A. D., Beck-Sagué, C. M., Szabó, R. G., Mercedes, F., Duke, W., ... Nicholas, S. (2009). HIV infection and prevention of mother-tochild transmission in childbearing women: La romana, Dominican republic, 2002-2006. Revista Panamericana de Salud Publica/Pan American Journal of Public Health, 26(4), 315-323.

HIV infection and prevention of mother-tochild transmission in childbearing women : La romana, Dominican republic, 2002-2006. / Román-Poueriet, José; Fernandez, Aracelis D.; Beck-Sagué, Consuelo M.; Szabó, René García; Mercedes, Fermin; Duke, William; Martinez, Anny; Nicholas, Stephen.

In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health, Vol. 26, No. 4, 10.2009, p. 315-323.

Research output: Contribution to journalArticle

Román-Poueriet, J, Fernandez, AD, Beck-Sagué, CM, Szabó, RG, Mercedes, F, Duke, W, Martinez, A & Nicholas, S 2009, 'HIV infection and prevention of mother-tochild transmission in childbearing women: La romana, Dominican republic, 2002-2006', Revista Panamericana de Salud Publica/Pan American Journal of Public Health, vol. 26, no. 4, pp. 315-323.
Román-Poueriet, José ; Fernandez, Aracelis D. ; Beck-Sagué, Consuelo M. ; Szabó, René García ; Mercedes, Fermin ; Duke, William ; Martinez, Anny ; Nicholas, Stephen. / HIV infection and prevention of mother-tochild transmission in childbearing women : La romana, Dominican republic, 2002-2006. In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health. 2009 ; Vol. 26, No. 4. pp. 315-323.
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abstract = "Objectives. To strengthen prevention of mother-to-child HIV transmission (pMTCT) program implementation in La Romana (LR) province, by estimating HIV prevalence and identifying characteristics associated with HIV infection in parturients. Methods. Umbilical cord blood samples were collected at seven obstetrical sites where over 95{\%} of LR's deliveries occur during four phases (pilot, expanded pilot, full study, and pMTCT program monitoring) from 2 August 2002 to 30 September 2006. Results were linked to data abstracted from delivery records. Results. HIV seroprevalence was 2.6{\%} (263/10 040 overall; 114/4 452, full-study phase (95{\%} confidence interval = 2.1{\%}-3.1{\%})). Most HIV-infected parturients were Dominican (68.9{\%}) and urban (64.0{\%}). However, prevalence was higher among Haitians (3.7{\%}) than Dominicans (2.3{\%} (p < 0.001)), especially those aged 21-25 years (5.2{\%} vs. 2.3{\%} (p < 0.001)), and among rural, batey, and peri-urban (vs. urban) parturients (3.4{\%} vs. 2.3{\%}, (p = 0.003)). HIV prevalence was associated with commercial sex work (reported by only 0.4{\%}), and prior pregnancy. In logistic regression analysis, commercial sex work, Haitian nationality, and prior pregnancy were independently associated with HIV infection. Caesarean deliveries were more frequent, and rose in the last years of the study, among HIV seropositives; however, most deliveries among seropositives (57.5{\%}) were vaginal. Conclusions. HIV prevalence among LR parturients was higher than the estimated prevalence in the Dominican Republic (0.8{\%}-1.0{\%}) and, in contrast to past studies, predominantly affected urban Dominicans. HIV prevalence among LR Haitian parturients was higher than among Dominican counterparts and prenatal clinic attendees in Haiti (who had a rate of 3.1{\%}). Consistently implemented, targeted pMTCT interventions are needed.",
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