HIV envelope gp120 activates human arterial smooth muscle cells

Alison D. Schecter, Adriane B. Berman, Lin Yi, Arevik Mosoian, Carrie M. McManus, Joan W. Berman, Mary E. Klotman, Mark B. Taubman

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

There have been increasing reports of acute coronary thrombotic events in patients with HIV. Although these clinical events have been attributed primarily to dyslipidemia associated with protease inhibitor therapy, autopsy studies in children with HIV suggest the presence of an underlying arteriopathy. This study demonstrates that the HIV envelope protein, gp120, activates human arterial smooth muscle cells to express tissue factor, the initiator of the coagulation cascade. The induction of tissue factor by gp120 is mediated by two biologically relevant coreceptors for HIV infection, CXCR4 and CCR5, and is also dependent on the presence of functional CD4. Induction of tissue factor by gp120 requires activation of mitogen-activating protein kinases, activation of protein kinase C, and generation of reactive oxygen species, signaling pathways that have protean effects on smooth muscle cell physiology. The activation of smooth muscle cells by gp120 may play an important role in the vascular, thrombotic, and inflammatory responses to HIV infection.

Original languageEnglish (US)
Pages (from-to)10142-10147
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number18
DOIs
StatePublished - Aug 28 2001

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'HIV envelope gp120 activates human arterial smooth muscle cells'. Together they form a unique fingerprint.

  • Cite this

    Schecter, A. D., Berman, A. B., Yi, L., Mosoian, A., McManus, C. M., Berman, J. W., Klotman, M. E., & Taubman, M. B. (2001). HIV envelope gp120 activates human arterial smooth muscle cells. Proceedings of the National Academy of Sciences of the United States of America, 98(18), 10142-10147. https://doi.org/10.1073/pnas.181328798