HIV and bone loss

Shitij Arora, Manasi Agrawal, Li Sun, Frantz Duffoo, Mone Zaidi, Jameel Iqbal

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

The use of antiretroviral therapy has significantly reduced the number of deaths due to HIV/AIDS. However, no current therapy can suppress the virus completely, and as the HIV-infected population continues to live longer new complications are emerging from the persistence of the virus and use of antiretroviral therapy. This review summarizes the clinical evidence linking HIV-associated osteoporosis to direct infection and antiretroviral therapy (ART) use. The purported molecular mechanisms involved in bone loss are also reviewed. Additionally, recommendations regarding the pharmacologic management of HIV/ART-related osteoporosis are given.

Original languageEnglish (US)
Pages (from-to)219-226
Number of pages8
JournalCurrent Osteoporosis Reports
Volume8
Issue number4
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Keywords

  • AIDS
  • BMD
  • Bone loss
  • HIV
  • Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
  • Nucleoside reverse transcriptase inhibitors (NRTIs)
  • Protease inhibitors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'HIV and bone loss'. Together they form a unique fingerprint.

  • Cite this

    Arora, S., Agrawal, M., Sun, L., Duffoo, F., Zaidi, M., & Iqbal, J. (2010). HIV and bone loss. Current Osteoporosis Reports, 8(4), 219-226. https://doi.org/10.1007/s11914-010-0036-x