Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock

Luciano DiTacchio, Hiep D. Le, Christopher Vollmers, Megumi Hatori, Michael Witcher, Julie Secombe, Satchidananda Panda

Research output: Contribution to journalArticle

138 Scopus citations

Abstract

In animals, circadian oscillators are based on a transcription-translation circuit that revolves around the transcription factors CLOCK and BMAL1. We found that the JumonjiC (JmjC) and ARID domain - containing histone lysine demethylase 1a (JARID1a) formed a complex with CLOCK-BMAL1, which was recruited to the Per2 promoter. JARID1a increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcription by CLOCK-BMAL1 in a demethylase-independent manner. Depletion of JARID1a in mammalian cells reduced Per promoter histone acetylation, dampened expression of canonical circadian genes, and shortened the period of circadian rhythms. Drosophila lines with reduced expression of the Jarid1a homolog, lid, had lowered Per expression and similarly altered circadian rhythms. JARID1a thus has a nonredundant role in circadian oscillator function.

Original languageEnglish (US)
Pages (from-to)1881-1885
Number of pages5
JournalScience
Volume333
Issue number6051
DOIs
StatePublished - Sep 30 2011

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this

DiTacchio, L., Le, H. D., Vollmers, C., Hatori, M., Witcher, M., Secombe, J., & Panda, S. (2011). Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science, 333(6051), 1881-1885. https://doi.org/10.1126/science.1206022