Hirano bodies and related neuronal inclusions

A. Hirano

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Hirano bodies are bright eosinophilic intracytoplasmic inclusions which have a highly characteristic crystalloid fine structure. They occur preferentially in the neuronal processes of the CA1 area in Ammon's horn in a wide variety of conditions, especially amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam, Alzheimer's disease, Pick's disease and 'normal' elderly individuals. Hirano bodies contain epitopes of actin, actin-associated proteins. tau, middle molecular weight neurofilaments subunit and a C-terminal fragment of β-amyloid precursor protein. In addition to the CA1 area of Ammon's horn, they have also been identified in many other areas of the nervous system in humans and various experimental animals. Although usually observed in neurons. Hirano bodies may also be present in other cell types. It is the consensus that Hirano bodies in the pyramidal layer of CA1 originate largely from an age-related alteration of the microfilamentous system.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalNeuropathology and Applied Neurobiology
Volume20
Issue number1
StatePublished - 1994

Fingerprint

Amyotrophic Lateral Sclerosis
Actins
Hippocampus
Pick Disease of the Brain
Intermediate Filaments
Amyloid beta-Protein Precursor
Nervous System
Epitopes
Consensus
Alzheimer Disease
Molecular Weight
Neurons
Proteins
crystalloid solutions

Keywords

  • Actin
  • Ammon's horn
  • Electron microscopy
  • Hirano bodies
  • Immunohistochemistry
  • Intraneuronal inclusions

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Hirano bodies and related neuronal inclusions. / Hirano, A.

In: Neuropathology and Applied Neurobiology, Vol. 20, No. 1, 1994, p. 3-11.

Research output: Contribution to journalArticle

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