Hirano bodies and Alzheimer's disease.

S. Mitake, K. Ojika, A. Hirano

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Hirano bodies are refractile eosinophilic rod-like structures, initially observed in Guamanian (Chamorro) patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex. Subsequent investigations revealed that Hirano bodies have a distinct topographic distribution in the hippocampus, and that their number increases in the pyramidal layer of Sommer's sector but not in the stratum lacunosum with advancing age. Since patients with Alzheimer's disease (AD) have significantly more Hirano bodies than normal subjects in the same age range, the inclusions appear seem to be of relevance in this disease. Immunohistochemical and electron microscopic studies have demonstrated that the main components of Hirano bodies are abnormal micro-filaments, and that not only molecules associated with cell cytoskeleton, but also some stress-related proteins and growth factors such as beta-amyloid precursor protein, hippocampal cholinergic neurostimulating peptide (HCNP), transforming growth factor beta 3 are present in Hirano bodies. The accumulation of HCNP in Hirano bodies suggests that patients bearing these inclusions may have a disturbance of the septohippocampal cholinergic system, considered to be of importance for le arning and memory formation, and hence be related to the memory impairment of AD.

Original languageEnglish (US)
Pages (from-to)10-18
Number of pages9
JournalThe Kaohsiung journal of medical sciences
Volume13
Issue number1
StatePublished - Jan 1997

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Alzheimer Disease
Amyloid beta-Protein Precursor
Amyotrophic Lateral Sclerosis
Parkinsonian Disorders
Heat-Shock Proteins
Cytoskeleton
Transforming Growth Factor beta
Cholinergic Agents
Hippocampus
Intercellular Signaling Peptides and Proteins
Electrons
hippocampal cholinergic neurostimulating peptide

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mitake, S., Ojika, K., & Hirano, A. (1997). Hirano bodies and Alzheimer's disease. The Kaohsiung journal of medical sciences, 13(1), 10-18.

Hirano bodies and Alzheimer's disease. / Mitake, S.; Ojika, K.; Hirano, A.

In: The Kaohsiung journal of medical sciences, Vol. 13, No. 1, 01.1997, p. 10-18.

Research output: Contribution to journalArticle

Mitake, S, Ojika, K & Hirano, A 1997, 'Hirano bodies and Alzheimer's disease.', The Kaohsiung journal of medical sciences, vol. 13, no. 1, pp. 10-18.
Mitake S, Ojika K, Hirano A. Hirano bodies and Alzheimer's disease. The Kaohsiung journal of medical sciences. 1997 Jan;13(1):10-18.
Mitake, S. ; Ojika, K. ; Hirano, A. / Hirano bodies and Alzheimer's disease. In: The Kaohsiung journal of medical sciences. 1997 ; Vol. 13, No. 1. pp. 10-18.
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