Higher biomarker-calibrated protein intake is not associated with impaired renal function in postmenopausal women

Jeannette M. Beasley, Aaron K. Aragaki, Andrea Z. LaCroix, Marian L. Neuhouser, Lesley F. Tinker, Jane A. Cauley, Kristine E. Ensrud, Rebecca D. Jackson, Ross L. Prentice

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

With aging, renal function tends to decline, as evidenced by reduced glomerular filtration rate. High-protein intake may further stress the kidneys by causing sustained hyperfiltration. To investigate whether dietary protein is associated with impaired renal function, we used data from 2 nested case-control studies within the Women's Health Initiative Observational Study (n = 2419). We estimated protein intake using a FFQ and estimated glomerular filtration rate (eGFR) from cystatin C. To account for the original study designs, inverse probability weights were applied. Self-reported energy and protein were calibrated using biomarkers of energy and protein intake. Associations between protein intake and renal function were estimated by weighted linear and logistic regression models. Average calibrated protein intake (mean± SD) was 1.1 ± 0.2 g/(kg body weight·d).Twelve percent (n = 292) of women had impaired renal function. The odds of impaired renal function, defined as eGFR <60 mL/(min·1.73m 2), was not associated with calibrated protein intake. When eGFR was modeled continuously, there was no association with calibrated protein when protein was expressed in absolute (g/d) or relative to energy (protein % energy/d), but protein relative to body weight [g/(kg body weight·d)] was associated with higher eGFR. There was no evidence for effect modification by age, BMI, or general health status. These data suggest higher protein intake is not associated with impaired renal function among postmenopausal women without a diagnosis of chronic kidney disease.

Original languageEnglish (US)
Pages (from-to)1502-1507
Number of pages6
JournalJournal of Nutrition
Volume141
Issue number8
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

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Biomarkers
Kidney
Glomerular Filtration Rate
Proteins
Logistic Models
Cystatin C
Dietary Proteins
Women's Health
Energy Intake
Chronic Renal Insufficiency
Health Status
Observational Studies
Case-Control Studies
Linear Models
Body Weight
Weights and Measures

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Beasley, J. M., Aragaki, A. K., LaCroix, A. Z., Neuhouser, M. L., Tinker, L. F., Cauley, J. A., ... Prentice, R. L. (2011). Higher biomarker-calibrated protein intake is not associated with impaired renal function in postmenopausal women. Journal of Nutrition, 141(8), 1502-1507. https://doi.org/10.3945/jn.110.135814

Higher biomarker-calibrated protein intake is not associated with impaired renal function in postmenopausal women. / Beasley, Jeannette M.; Aragaki, Aaron K.; LaCroix, Andrea Z.; Neuhouser, Marian L.; Tinker, Lesley F.; Cauley, Jane A.; Ensrud, Kristine E.; Jackson, Rebecca D.; Prentice, Ross L.

In: Journal of Nutrition, Vol. 141, No. 8, 01.08.2011, p. 1502-1507.

Research output: Contribution to journalArticle

Beasley, JM, Aragaki, AK, LaCroix, AZ, Neuhouser, ML, Tinker, LF, Cauley, JA, Ensrud, KE, Jackson, RD & Prentice, RL 2011, 'Higher biomarker-calibrated protein intake is not associated with impaired renal function in postmenopausal women', Journal of Nutrition, vol. 141, no. 8, pp. 1502-1507. https://doi.org/10.3945/jn.110.135814
Beasley, Jeannette M. ; Aragaki, Aaron K. ; LaCroix, Andrea Z. ; Neuhouser, Marian L. ; Tinker, Lesley F. ; Cauley, Jane A. ; Ensrud, Kristine E. ; Jackson, Rebecca D. ; Prentice, Ross L. / Higher biomarker-calibrated protein intake is not associated with impaired renal function in postmenopausal women. In: Journal of Nutrition. 2011 ; Vol. 141, No. 8. pp. 1502-1507.
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