High fat diet aggravates cardiomyopathy in murine chronic Chagas disease

Kezia Lizardo, Janeesh Plakkal Ayyappan, Min-Hui Cui, Rashmi Balasubramanya, Linda A. Jelicks, Jyothi F. Nagajyothi

Research output: Contribution to journalArticle

Abstract

Infection with Trypanosoma cruzi, the etiologic agent in Chagas disease, may result in heart disease. Over the last decades, Chagas disease endemic areas in Latin America have seen a dietary transition from the traditional regional diet to a Western style, fat rich diet. Previously, we demonstrated that during acute infection high fat diet (HFD) protects mice from the consequences of infection-induced myocardial damage through effects on adipogenesis in adipose tissue and reduced cardiac lipidopathy. However, the effect of HFD on the subsequent stages of infection – the indeterminate and chronic stages – has not been investigated. To address this gap in knowledge, we studied the effect of HFD during indeterminate and chronic stages of Chagas disease in the mouse model. We report, for the first time, the effect of HFD on myocardial inflammation, vasculopathy, and other types of dysfunction observed during chronic T. cruzi infection. Our results show that HFD perturbs lipid metabolism and induces oxidative stress to exacerbate late chronic Chagas disease cardiac pathology.

Original languageEnglish (US)
JournalMicrobes and Infection
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Chagas Disease
High Fat Diet
Cardiomyopathies
Chronic Disease
Infection
Trypanosoma cruzi
Diet
Adipogenesis
Latin America
Lipid Metabolism
Adipose Tissue
Heart Diseases
Oxidative Stress
Fats
Pathology
Inflammation

Keywords

  • Chagasic cardiomyopathy
  • High fat diet
  • Inflammation
  • Lipid metabolism
  • Mitochondrial dysfunction
  • RAGE

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Lizardo, K., Ayyappan, J. P., Cui, M-H., Balasubramanya, R., Jelicks, L. A., & Nagajyothi, J. F. (Accepted/In press). High fat diet aggravates cardiomyopathy in murine chronic Chagas disease. Microbes and Infection. https://doi.org/10.1016/j.micinf.2018.07.001

High fat diet aggravates cardiomyopathy in murine chronic Chagas disease. / Lizardo, Kezia; Ayyappan, Janeesh Plakkal; Cui, Min-Hui; Balasubramanya, Rashmi; Jelicks, Linda A.; Nagajyothi, Jyothi F.

In: Microbes and Infection, 01.01.2018.

Research output: Contribution to journalArticle

Lizardo, Kezia ; Ayyappan, Janeesh Plakkal ; Cui, Min-Hui ; Balasubramanya, Rashmi ; Jelicks, Linda A. ; Nagajyothi, Jyothi F. / High fat diet aggravates cardiomyopathy in murine chronic Chagas disease. In: Microbes and Infection. 2018.
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