Her-2 involvement in osteosarcoma

Jonathan Gill, David Geller, Richard Gorlick

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The major goals of translational research in osteosarcoma entail the identification of prognostic factors and therapeutic targets. Given the relevance of epidermal growth factor receptor pathway to breast cancer and the fi nding that HER-2 was expressed in a proportion of osteosarcoma, it was reasonable to investigate this pathway further. Investigations of HER-2 in osteosarcoma have led to the publication of numerous confl icting reports with regard to the level and prognostic value of HER-2 expression, which are reviewed and discussed. Numerous lessons provided by this research experience are described. This pathway has also been explored as a therapeutic target with at least one study of trastuzumab for the treatment of osteosarcoma completed. Other studies utilizing alternative approaches to target the HER-2 receptor for the treatment of osteosarcoma have been considered.

Original languageEnglish (US)
Pages (from-to)161-177
Number of pages17
JournalAdvances in experimental medicine and biology
Volume804
DOIs
StatePublished - Jan 1 2014

Keywords

  • Human epidermal growth factor receptor (HER-2)
  • Immunohistochemistry
  • Osteosarcoma
  • Targeted therapy
  • Trastuzumab

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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