Hepatocyte transplantation for the treatment of human disease

Stephen C. Strom, Jayanta Roy Chowdhury, Ira J. Fox

Research output: Contribution to journalReview article

311 Scopus citations

Abstract

A great deal of work with animal models indicates that hepatocytes transplanted into the liver or spleen survive, function, and participate in the normal regenerative process. Recent clinical studies suggest that hepatocyte transplantation may be useful for bridging patients to whole organ transplantation and for providing metabolic support during liver failure and for replacing whole organ transplantation in certain metabolic liver diseases. In specific situations where the rate of death of host hepatocytes is high, the transplanted cells can repopulate the native liver. Techniques have been established for the large scale isolation, culture, and cryopreservation of human hepatocytes. Shortage of donor organs and the need for immunosuppression are two major hurdles to widespread application of this procedure, and current research in experimental animals is aimed at addressing these problems.

Original languageEnglish (US)
Pages (from-to)39-48
Number of pages10
JournalSeminars in Liver Disease
Volume19
Issue number1
DOIs
StatePublished - Jan 1 1999

Keywords

  • Hepatocyte
  • Transplantation

ASJC Scopus subject areas

  • Hepatology

Cite this