Hepatocellular carcinoma radiation therapy: Review of evidence and future opportunities

Jonathan H. Klein, Laura A. Dawson

Research output: Contribution to journalReview article

111 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Curative therapy is not an option for most patients, often because of underlying liver disease. Experience in radiation therapy (RT) for HCC is rapidly increasing. Conformal RT can deliver tumoricidal doses to focal HCC with low rates of toxicity and sustained local control in HCC unsuitable for other locoregional treatments. Stereotactic body RT and particle therapy have been used with long-term control in early HCC or as a bridge to liver transplant. RT has also been effective in treating HCC with portal venous thrombosis. Patients with impaired liver function and extensive disease are at increased risk of toxicity and recurrence. More research on how to combine RT with other standard and novel therapies is warranted. Randomized trials are also needed before RT will be generally accepted as a treatment option for HCC. This review discusses the current state of the literature and opportunities for future research.

Original languageEnglish (US)
Pages (from-to)22-32
Number of pages11
JournalInternational Journal of Radiation Oncology Biology Physics
Volume87
Issue number1
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

Fingerprint

Hepatocellular Carcinoma
radiation therapy
Radiotherapy
cancer
liver
therapy
toxicity
Therapeutics
thrombosis
Liver
Venous Thrombosis
Liver Diseases
death
Transplants
Recurrence
dosage
causes
Research
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Hepatocellular carcinoma radiation therapy : Review of evidence and future opportunities. / Klein, Jonathan H.; Dawson, Laura A.

In: International Journal of Radiation Oncology Biology Physics, Vol. 87, No. 1, 01.09.2013, p. 22-32.

Research output: Contribution to journalReview article

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