Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals

Gregory M. Lucas, Yuezhou Jing, Mark Sulkowski, Alison G. Abraham, Michelle M. Estrella, Mohamed G. Atta, Derek M. Fine, Marina B. Klein, Michael J. Silverberg, M. John Gill, Richard D. Moore, Kelly A. Gebo, Timothy R. Sterling, Adeel A. Butt, Gregory D. Kirk, Constance A. Benson, Ronald J. Bosch, Ann C. Collier, Stephen Boswell, Chris Grasso & 54 others Ken Mayer, Robert S. Hogg, Richard Harrigan, Julio Montaner, Angela Cescon, John T. Brooks, Kate Buchacz, John T. Carey, Benigno Rodriguez, Michael A. Horberg, Jennifer E. Thorne, James J. Goedert, Lisa P. Jacobson, Sean B. Rourke, Ann Burchell, Anita R. Rachlis, Puerto Rico, Robert F. Hunter-Mellado, Angel M. Mayor, Steven G. Deeks, Jeffrey N. Martin, Pragna Patel, Michael S. Saag, Michael J. Mugavero, James Willig, Joseph J. Eron, Sonia Napravnik, Mari M. Kitahata, Heidi M. Crane, Amy C. Justice, Robert Dubrow, David Fiellin, David Haas, Sally Bebawy, Megan Turner, Stephen J. Gange, Kathryn Anastos, Rosemary G. McKaig, Aimee M. Freeman, Carol Lent, Stephen E. Van Rompaey, Eric Webster, Liz Morton, Brenda Simon, Keri N. Althoff, Bryan Lau, Jinbing Zhang, Jerry Jing, Elizabeth Golub, Shari Modur, David B. Hanna, Peter Rebeiro, Cherise Wong, Adell Mendes

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background. The role of active hepatitis C virus (HCV) replication in chronic kidney disease (CKD) risk has not been clarified.Methods. We compared CKD incidence in a large cohort of HIV-infected subjects who were HCV seronegative, HCV viremic (detectable HCV RNA), or HCV aviremic (HCV seropositive, undetectable HCV RNA). Stages 3 and 5 CKD were defined according to standard criteria. Progressive CKD was defined as a sustained 25% glomerular filtration rate (GFR) decrease from baseline to a GFR < 60 mL/min/1.73 m 2. We used Cox models to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).Results. A total of 52 602 HCV seronegative, 9508 HCV viremic, and 913 HCV aviremic subjects were included. Compared with HCV seronegative subjects, HCV viremic subjects were at increased risk for stage 3 CKD (adjusted HR 1.36 [95% CI, 1.26, 1.46]), stage 5 CKD (1.95 [1.64, 2.31]), and progressive CKD (1.31 [1.19, 1.44]), while HCV aviremic subjects were also at increased risk for stage 3 CKD (1.19 [0.98, 1.45]), stage 5 CKD (1.69 [1.07, 2.65]), and progressive CKD (1.31 [1.02, 1.68]).Conclusions. Compared with HIV-infected subjects who were HCV seronegative, both HCV viremic and HCV aviremic individuals were at increased risk for moderate and advanced CKD.

Original languageEnglish (US)
Pages (from-to)1240-1249
Number of pages10
JournalJournal of Infectious Diseases
Volume208
Issue number8
DOIs
StatePublished - Oct 15 2013
Externally publishedYes

Fingerprint

Viremia
Hepatitis C
Chronic Renal Insufficiency
Hepacivirus
HIV
Glomerular Filtration Rate
RNA
Confidence Intervals
Virus Replication
Proportional Hazards Models

Keywords

  • chronic kidney disease
  • cohort study
  • glomerular filtration rate
  • hepatitis C RNA
  • hepatitis C virus
  • HIV
  • injection drug use

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Lucas, G. M., Jing, Y., Sulkowski, M., Abraham, A. G., Estrella, M. M., Atta, M. G., ... Mendes, A. (2013). Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals. Journal of Infectious Diseases, 208(8), 1240-1249. https://doi.org/10.1093/infdis/jit373

Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals. / Lucas, Gregory M.; Jing, Yuezhou; Sulkowski, Mark; Abraham, Alison G.; Estrella, Michelle M.; Atta, Mohamed G.; Fine, Derek M.; Klein, Marina B.; Silverberg, Michael J.; Gill, M. John; Moore, Richard D.; Gebo, Kelly A.; Sterling, Timothy R.; Butt, Adeel A.; Kirk, Gregory D.; Benson, Constance A.; Bosch, Ronald J.; Collier, Ann C.; Boswell, Stephen; Grasso, Chris; Mayer, Ken; Hogg, Robert S.; Harrigan, Richard; Montaner, Julio; Cescon, Angela; Brooks, John T.; Buchacz, Kate; Carey, John T.; Rodriguez, Benigno; Horberg, Michael A.; Thorne, Jennifer E.; Goedert, James J.; Jacobson, Lisa P.; Rourke, Sean B.; Burchell, Ann; Rachlis, Anita R.; Rico, Puerto; Hunter-Mellado, Robert F.; Mayor, Angel M.; Deeks, Steven G.; Martin, Jeffrey N.; Patel, Pragna; Saag, Michael S.; Mugavero, Michael J.; Willig, James; Eron, Joseph J.; Napravnik, Sonia; Kitahata, Mari M.; Crane, Heidi M.; Justice, Amy C.; Dubrow, Robert; Fiellin, David; Haas, David; Bebawy, Sally; Turner, Megan; Gange, Stephen J.; Anastos, Kathryn; McKaig, Rosemary G.; Freeman, Aimee M.; Lent, Carol; Van Rompaey, Stephen E.; Webster, Eric; Morton, Liz; Simon, Brenda; Althoff, Keri N.; Lau, Bryan; Zhang, Jinbing; Jing, Jerry; Golub, Elizabeth; Modur, Shari; Hanna, David B.; Rebeiro, Peter; Wong, Cherise; Mendes, Adell.

In: Journal of Infectious Diseases, Vol. 208, No. 8, 15.10.2013, p. 1240-1249.

Research output: Contribution to journalArticle

Lucas, GM, Jing, Y, Sulkowski, M, Abraham, AG, Estrella, MM, Atta, MG, Fine, DM, Klein, MB, Silverberg, MJ, Gill, MJ, Moore, RD, Gebo, KA, Sterling, TR, Butt, AA, Kirk, GD, Benson, CA, Bosch, RJ, Collier, AC, Boswell, S, Grasso, C, Mayer, K, Hogg, RS, Harrigan, R, Montaner, J, Cescon, A, Brooks, JT, Buchacz, K, Carey, JT, Rodriguez, B, Horberg, MA, Thorne, JE, Goedert, JJ, Jacobson, LP, Rourke, SB, Burchell, A, Rachlis, AR, Rico, P, Hunter-Mellado, RF, Mayor, AM, Deeks, SG, Martin, JN, Patel, P, Saag, MS, Mugavero, MJ, Willig, J, Eron, JJ, Napravnik, S, Kitahata, MM, Crane, HM, Justice, AC, Dubrow, R, Fiellin, D, Haas, D, Bebawy, S, Turner, M, Gange, SJ, Anastos, K, McKaig, RG, Freeman, AM, Lent, C, Van Rompaey, SE, Webster, E, Morton, L, Simon, B, Althoff, KN, Lau, B, Zhang, J, Jing, J, Golub, E, Modur, S, Hanna, DB, Rebeiro, P, Wong, C & Mendes, A 2013, 'Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals', Journal of Infectious Diseases, vol. 208, no. 8, pp. 1240-1249. https://doi.org/10.1093/infdis/jit373
Lucas GM, Jing Y, Sulkowski M, Abraham AG, Estrella MM, Atta MG et al. Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals. Journal of Infectious Diseases. 2013 Oct 15;208(8):1240-1249. https://doi.org/10.1093/infdis/jit373
Lucas, Gregory M. ; Jing, Yuezhou ; Sulkowski, Mark ; Abraham, Alison G. ; Estrella, Michelle M. ; Atta, Mohamed G. ; Fine, Derek M. ; Klein, Marina B. ; Silverberg, Michael J. ; Gill, M. John ; Moore, Richard D. ; Gebo, Kelly A. ; Sterling, Timothy R. ; Butt, Adeel A. ; Kirk, Gregory D. ; Benson, Constance A. ; Bosch, Ronald J. ; Collier, Ann C. ; Boswell, Stephen ; Grasso, Chris ; Mayer, Ken ; Hogg, Robert S. ; Harrigan, Richard ; Montaner, Julio ; Cescon, Angela ; Brooks, John T. ; Buchacz, Kate ; Carey, John T. ; Rodriguez, Benigno ; Horberg, Michael A. ; Thorne, Jennifer E. ; Goedert, James J. ; Jacobson, Lisa P. ; Rourke, Sean B. ; Burchell, Ann ; Rachlis, Anita R. ; Rico, Puerto ; Hunter-Mellado, Robert F. ; Mayor, Angel M. ; Deeks, Steven G. ; Martin, Jeffrey N. ; Patel, Pragna ; Saag, Michael S. ; Mugavero, Michael J. ; Willig, James ; Eron, Joseph J. ; Napravnik, Sonia ; Kitahata, Mari M. ; Crane, Heidi M. ; Justice, Amy C. ; Dubrow, Robert ; Fiellin, David ; Haas, David ; Bebawy, Sally ; Turner, Megan ; Gange, Stephen J. ; Anastos, Kathryn ; McKaig, Rosemary G. ; Freeman, Aimee M. ; Lent, Carol ; Van Rompaey, Stephen E. ; Webster, Eric ; Morton, Liz ; Simon, Brenda ; Althoff, Keri N. ; Lau, Bryan ; Zhang, Jinbing ; Jing, Jerry ; Golub, Elizabeth ; Modur, Shari ; Hanna, David B. ; Rebeiro, Peter ; Wong, Cherise ; Mendes, Adell. / Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals. In: Journal of Infectious Diseases. 2013 ; Vol. 208, No. 8. pp. 1240-1249.
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title = "Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals",
abstract = "Background. The role of active hepatitis C virus (HCV) replication in chronic kidney disease (CKD) risk has not been clarified.Methods. We compared CKD incidence in a large cohort of HIV-infected subjects who were HCV seronegative, HCV viremic (detectable HCV RNA), or HCV aviremic (HCV seropositive, undetectable HCV RNA). Stages 3 and 5 CKD were defined according to standard criteria. Progressive CKD was defined as a sustained 25{\%} glomerular filtration rate (GFR) decrease from baseline to a GFR < 60 mL/min/1.73 m 2. We used Cox models to calculate adjusted hazard ratios (HRs) and 95{\%} confidence intervals (CIs).Results. A total of 52 602 HCV seronegative, 9508 HCV viremic, and 913 HCV aviremic subjects were included. Compared with HCV seronegative subjects, HCV viremic subjects were at increased risk for stage 3 CKD (adjusted HR 1.36 [95{\%} CI, 1.26, 1.46]), stage 5 CKD (1.95 [1.64, 2.31]), and progressive CKD (1.31 [1.19, 1.44]), while HCV aviremic subjects were also at increased risk for stage 3 CKD (1.19 [0.98, 1.45]), stage 5 CKD (1.69 [1.07, 2.65]), and progressive CKD (1.31 [1.02, 1.68]).Conclusions. Compared with HIV-infected subjects who were HCV seronegative, both HCV viremic and HCV aviremic individuals were at increased risk for moderate and advanced CKD.",
keywords = "chronic kidney disease, cohort study, glomerular filtration rate, hepatitis C RNA, hepatitis C virus, HIV, injection drug use",
author = "Lucas, {Gregory M.} and Yuezhou Jing and Mark Sulkowski and Abraham, {Alison G.} and Estrella, {Michelle M.} and Atta, {Mohamed G.} and Fine, {Derek M.} and Klein, {Marina B.} and Silverberg, {Michael J.} and Gill, {M. John} and Moore, {Richard D.} and Gebo, {Kelly A.} and Sterling, {Timothy R.} and Butt, {Adeel A.} and Kirk, {Gregory D.} and Benson, {Constance A.} and Bosch, {Ronald J.} and Collier, {Ann C.} and Stephen Boswell and Chris Grasso and Ken Mayer and Hogg, {Robert S.} and Richard Harrigan and Julio Montaner and Angela Cescon and Brooks, {John T.} and Kate Buchacz and Carey, {John T.} and Benigno Rodriguez and Horberg, {Michael A.} and Thorne, {Jennifer E.} and Goedert, {James J.} and Jacobson, {Lisa P.} and Rourke, {Sean B.} and Ann Burchell and Rachlis, {Anita R.} and Puerto Rico and Hunter-Mellado, {Robert F.} and Mayor, {Angel M.} and Deeks, {Steven G.} and Martin, {Jeffrey N.} and Pragna Patel and Saag, {Michael S.} and Mugavero, {Michael J.} and James Willig and Eron, {Joseph J.} and Sonia Napravnik and Kitahata, {Mari M.} and Crane, {Heidi M.} and Justice, {Amy C.} and Robert Dubrow and David Fiellin and David Haas and Sally Bebawy and Megan Turner and Gange, {Stephen J.} and Kathryn Anastos and McKaig, {Rosemary G.} and Freeman, {Aimee M.} and Carol Lent and {Van Rompaey}, {Stephen E.} and Eric Webster and Liz Morton and Brenda Simon and Althoff, {Keri N.} and Bryan Lau and Jinbing Zhang and Jerry Jing and Elizabeth Golub and Shari Modur and Hanna, {David B.} and Peter Rebeiro and Cherise Wong and Adell Mendes",
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month = "10",
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TY - JOUR

T1 - Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals

AU - Lucas, Gregory M.

AU - Jing, Yuezhou

AU - Sulkowski, Mark

AU - Abraham, Alison G.

AU - Estrella, Michelle M.

AU - Atta, Mohamed G.

AU - Fine, Derek M.

AU - Klein, Marina B.

AU - Silverberg, Michael J.

AU - Gill, M. John

AU - Moore, Richard D.

AU - Gebo, Kelly A.

AU - Sterling, Timothy R.

AU - Butt, Adeel A.

AU - Kirk, Gregory D.

AU - Benson, Constance A.

AU - Bosch, Ronald J.

AU - Collier, Ann C.

AU - Boswell, Stephen

AU - Grasso, Chris

AU - Mayer, Ken

AU - Hogg, Robert S.

AU - Harrigan, Richard

AU - Montaner, Julio

AU - Cescon, Angela

AU - Brooks, John T.

AU - Buchacz, Kate

AU - Carey, John T.

AU - Rodriguez, Benigno

AU - Horberg, Michael A.

AU - Thorne, Jennifer E.

AU - Goedert, James J.

AU - Jacobson, Lisa P.

AU - Rourke, Sean B.

AU - Burchell, Ann

AU - Rachlis, Anita R.

AU - Rico, Puerto

AU - Hunter-Mellado, Robert F.

AU - Mayor, Angel M.

AU - Deeks, Steven G.

AU - Martin, Jeffrey N.

AU - Patel, Pragna

AU - Saag, Michael S.

AU - Mugavero, Michael J.

AU - Willig, James

AU - Eron, Joseph J.

AU - Napravnik, Sonia

AU - Kitahata, Mari M.

AU - Crane, Heidi M.

AU - Justice, Amy C.

AU - Dubrow, Robert

AU - Fiellin, David

AU - Haas, David

AU - Bebawy, Sally

AU - Turner, Megan

AU - Gange, Stephen J.

AU - Anastos, Kathryn

AU - McKaig, Rosemary G.

AU - Freeman, Aimee M.

AU - Lent, Carol

AU - Van Rompaey, Stephen E.

AU - Webster, Eric

AU - Morton, Liz

AU - Simon, Brenda

AU - Althoff, Keri N.

AU - Lau, Bryan

AU - Zhang, Jinbing

AU - Jing, Jerry

AU - Golub, Elizabeth

AU - Modur, Shari

AU - Hanna, David B.

AU - Rebeiro, Peter

AU - Wong, Cherise

AU - Mendes, Adell

PY - 2013/10/15

Y1 - 2013/10/15

N2 - Background. The role of active hepatitis C virus (HCV) replication in chronic kidney disease (CKD) risk has not been clarified.Methods. We compared CKD incidence in a large cohort of HIV-infected subjects who were HCV seronegative, HCV viremic (detectable HCV RNA), or HCV aviremic (HCV seropositive, undetectable HCV RNA). Stages 3 and 5 CKD were defined according to standard criteria. Progressive CKD was defined as a sustained 25% glomerular filtration rate (GFR) decrease from baseline to a GFR < 60 mL/min/1.73 m 2. We used Cox models to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).Results. A total of 52 602 HCV seronegative, 9508 HCV viremic, and 913 HCV aviremic subjects were included. Compared with HCV seronegative subjects, HCV viremic subjects were at increased risk for stage 3 CKD (adjusted HR 1.36 [95% CI, 1.26, 1.46]), stage 5 CKD (1.95 [1.64, 2.31]), and progressive CKD (1.31 [1.19, 1.44]), while HCV aviremic subjects were also at increased risk for stage 3 CKD (1.19 [0.98, 1.45]), stage 5 CKD (1.69 [1.07, 2.65]), and progressive CKD (1.31 [1.02, 1.68]).Conclusions. Compared with HIV-infected subjects who were HCV seronegative, both HCV viremic and HCV aviremic individuals were at increased risk for moderate and advanced CKD.

AB - Background. The role of active hepatitis C virus (HCV) replication in chronic kidney disease (CKD) risk has not been clarified.Methods. We compared CKD incidence in a large cohort of HIV-infected subjects who were HCV seronegative, HCV viremic (detectable HCV RNA), or HCV aviremic (HCV seropositive, undetectable HCV RNA). Stages 3 and 5 CKD were defined according to standard criteria. Progressive CKD was defined as a sustained 25% glomerular filtration rate (GFR) decrease from baseline to a GFR < 60 mL/min/1.73 m 2. We used Cox models to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).Results. A total of 52 602 HCV seronegative, 9508 HCV viremic, and 913 HCV aviremic subjects were included. Compared with HCV seronegative subjects, HCV viremic subjects were at increased risk for stage 3 CKD (adjusted HR 1.36 [95% CI, 1.26, 1.46]), stage 5 CKD (1.95 [1.64, 2.31]), and progressive CKD (1.31 [1.19, 1.44]), while HCV aviremic subjects were also at increased risk for stage 3 CKD (1.19 [0.98, 1.45]), stage 5 CKD (1.69 [1.07, 2.65]), and progressive CKD (1.31 [1.02, 1.68]).Conclusions. Compared with HIV-infected subjects who were HCV seronegative, both HCV viremic and HCV aviremic individuals were at increased risk for moderate and advanced CKD.

KW - chronic kidney disease

KW - cohort study

KW - glomerular filtration rate

KW - hepatitis C RNA

KW - hepatitis C virus

KW - HIV

KW - injection drug use

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U2 - 10.1093/infdis/jit373

DO - 10.1093/infdis/jit373

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SP - 1240

EP - 1249

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

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