Heparin administered to 8 patients undergoing hemodialysis for chronic renal disease resulted in a decrease in plasma protein binding of thyroxine (T4), in confirmation of the report by Schatz et al. (J Clin Endocrinol 29: 1015, 1969). Despite this, there was no apparent shift of labeled T4 from plasma protein to the rapidly exchangeable cellular compartment. Since the partition of T4 between plasma proteins and cells is determined by the balance between plasma protein and cellular binding, these observations suggest that heparin administered in vivo reduces cellular as well as plasma protein binding.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry
- Biochemistry, medical