Heparin administration appears to decrease cellular binding of thyroxine

Harold L. Schwartz; Alan R. Schadlow; Daniel Faierman; Martin I. Surks; Jack H. Oppenheimer

doi:10.1210/jcem-36-3-598

Heparin administration appears to decrease cellular binding of thyroxine

Harold L. Schwartz, Alan R. Schadlow, Daniel Faierman, Martin I. Surks, Jack H. Oppenheimer

Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Heparin administered to 8 patients undergoing hemodialysis for chronic renal disease resulted in a decrease in plasma protein binding of thyroxine (T₄), in confirmation of the report by Schatz et al. (J Clin Endocrinol 29: 1015, 1969). Despite this, there was no apparent shift of labeled T₄ from plasma protein to the rapidly exchangeable cellular compartment. Since the partition of T₄ between plasma proteins and cells is determined by the balance between plasma protein and cellular binding, these observations suggest that heparin administered in vivo reduces cellular as well as plasma protein binding.

Original language	English (US)
Pages (from-to)	598-600
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	36
Issue number	3
DOIs	https://doi.org/10.1210/jcem-36-3-598
State	Published - Mar 1973

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-36-3-598

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AU - Schadlow, Alan R.

AU - Faierman, Daniel

AU - Surks, Martin I.

AU - Oppenheimer, Jack H.

PY - 1973/3

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AB - Heparin administered to 8 patients undergoing hemodialysis for chronic renal disease resulted in a decrease in plasma protein binding of thyroxine (T4), in confirmation of the report by Schatz et al. (J Clin Endocrinol 29: 1015, 1969). Despite this, there was no apparent shift of labeled T4 from plasma protein to the rapidly exchangeable cellular compartment. Since the partition of T4 between plasma proteins and cells is determined by the balance between plasma protein and cellular binding, these observations suggest that heparin administered in vivo reduces cellular as well as plasma protein binding.

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Heparin administration appears to decrease cellular binding of thyroxine

Abstract

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