Hemoglobinopathy screening in pregnancy: Comparison of two protocols

Stephen T. Chasen, Susan Loeb-Zeitlin, Ellen J. Landsberger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This study was designed to determine the ability of a hemoglobinopathy screening protocol involving sickle solubility testing and red blood cell (RBC) indices to identify at-risk pregnancies. Retrospective chart review of all patients registering for prenatal care at the New York Hospital/Cornell Medical Center prenatal clinic in 1996 was the study design. All patients had RBC indices as well as hemoglobin electrophoresis. RBC indices of those with normal and abnormal electrophoreses were compared. Comparison of protocols involving universal hemoglobin electrophoresis and selective use of hemoglobin electrophoresis were compared. Student's t-test was used for statistical analysis. There were 36 carriers of hemoglobinopathy traits in 631 patients screened (5.7%). Four (three with hemoglobin C trait and one with hemoglobin D trait) had nor mal RBC indices and presumably would have had negative sickle solubility testing. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of a protocol with selective use of hemoglobin electrophoresis would have been 88.9, 79.4, 20.8, and 99.2%, respectively. Cost analysis reveals a difference of $11,384 or $18/patient less in a protocol with selective use of hemoglobin electrophoresis. Although a protocol involving solubility testing with RBC indices will not identify every carrier of a hemoglobinopathy trait, it may be appropriate in some populations.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalAmerican Journal of Perinatology
Volume16
Issue number4
StatePublished - 1999
Externally publishedYes

Fingerprint

Hemoglobinopathies
Erythrocyte Indices
Electrophoresis
Hemoglobins
Erythrocytes
Pregnancy
Solubility
Hemoglobin C
Prenatal Care
Students
Costs and Cost Analysis
Sensitivity and Specificity
Population

Keywords

  • Genetic screening
  • Hemoglobinopathy
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Chasen, S. T., Loeb-Zeitlin, S., & Landsberger, E. J. (1999). Hemoglobinopathy screening in pregnancy: Comparison of two protocols. American Journal of Perinatology, 16(4), 175-180.

Hemoglobinopathy screening in pregnancy : Comparison of two protocols. / Chasen, Stephen T.; Loeb-Zeitlin, Susan; Landsberger, Ellen J.

In: American Journal of Perinatology, Vol. 16, No. 4, 1999, p. 175-180.

Research output: Contribution to journalArticle

Chasen, ST, Loeb-Zeitlin, S & Landsberger, EJ 1999, 'Hemoglobinopathy screening in pregnancy: Comparison of two protocols', American Journal of Perinatology, vol. 16, no. 4, pp. 175-180.
Chasen, Stephen T. ; Loeb-Zeitlin, Susan ; Landsberger, Ellen J. / Hemoglobinopathy screening in pregnancy : Comparison of two protocols. In: American Journal of Perinatology. 1999 ; Vol. 16, No. 4. pp. 175-180.
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