Hematologic manifestations in pediatric HIV infection

Severe anemia as a prognostic factor

Maadhava Ellaurie, Edward R. Burns, Arye Rubinstein

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The hematologic profile of 100 symptomatic children infected by the human immunodeficiency virus (HIV) was evaluated and compared to HIV uninfected infants with transplacentally acquired maternal anti-HIV antibodies, and to HIV-negative infants born to i.v. drug-abusing HIV uninfected mothers. Anemia was present in 94% of HIV-infected infants and was a major predictor of disease progression. In 91% of patients having a hematocrit (HcT) < 25%, the disease course was rapidly fatal. Leukopenia and thrombocytopenia occurred in 47 and 33% of HIV infected patients, respectively. Neutropenia was most severe in children with opportunistic infections. There was no evidence of suppression of any component of hematopoiesis by passively acquired antibodies to HIV.

Original languageEnglish (US)
Pages (from-to)449-453
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume12
Issue number4
StatePublished - 1990

Fingerprint

Virus Diseases
Anemia
HIV
Pediatrics
Mothers
Antibodies
Opportunistic Infections
Hematopoiesis
Leukopenia
Neutropenia
Hematocrit
Thrombocytopenia
Disease Progression
Pharmaceutical Preparations

Keywords

  • Anemia
  • Hematology
  • HIV
  • Leukopenia
  • Prognosis
  • Thrombocytopenia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

Hematologic manifestations in pediatric HIV infection : Severe anemia as a prognostic factor. / Ellaurie, Maadhava; Burns, Edward R.; Rubinstein, Arye.

In: Journal of Pediatric Hematology/Oncology, Vol. 12, No. 4, 1990, p. 449-453.

Research output: Contribution to journalArticle

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