Abstract
We describe a restriction enzyme-based approach to study cytosine methylation using massively parallel sequencing that balances cost efficiency with comprehensiveness in a way that is suitable for human disease studies of large patient cohorts.
Original language | English (US) |
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Title of host publication | Tag-Based Next Generation Sequencing |
Publisher | Wiley-VCH |
Pages | 299-309 |
Number of pages | 11 |
ISBN (Print) | 9783527328192 |
DOIs | |
State | Published - Jan 23 2012 |
Keywords
- Applications
- Cytosine methylation profiling
- Genome-wide
- HELP-tagging
- Methods
- Tag-based
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)