HELP-Tagging: Tag-Based Genome-Wide Cytosine Methylation Profiling

Research output: Chapter in Book/Report/Conference proceedingChapter


We describe a restriction enzyme-based approach to study cytosine methylation using massively parallel sequencing that balances cost efficiency with comprehensiveness in a way that is suitable for human disease studies of large patient cohorts.

Original languageEnglish (US)
Title of host publicationTag-Based Next Generation Sequencing
Number of pages11
ISBN (Print)9783527328192
StatePublished - Jan 23 2012


  • Applications
  • Cytosine methylation profiling
  • Genome-wide
  • HELP-tagging
  • Methods
  • Tag-based

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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