Harnessing the potential of radiation-induced immune modulation for cancer therapy

Mansoor M. Ahmed, James W. Hodge, Chandan Guha, Eric J. Bernhard, Bhadrasain Vikram, C. Norman Coleman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The conventional use of radiotherapy is for local tumor control. Radiotherapy of the primary tumor can prevent the development of distant metastases, but this modality is generally not effective for treating preexisting systemic disease. However, radiation-induced tumor destruction may be considered a novel strategy for in situ cancer vaccination, in which tumor antigens released from dying tumor cells may be presented in an immunostimulatory context. Moreover, radiation has been demonstrated to induce immunogenic modulation in various tumor types by altering the biology of surviving cells to render them more susceptible to T cell-mediated killing. Finally, radiotherapy typically has a favorable toxicity profile and is associated with the absence of systemic immunosuppression. Together, these properties suggest that radiotherapy may serve as an important component of combinatorial immunotherapies aimed at augmenting systemic antitumor immunity. Here, we provide an overview of the radiation-induced modulations of the immune system that may be harnessed for cancer therapy.

Original languageEnglish (US)
Pages (from-to)280-284
Number of pages5
JournalCancer immunology research
Volume1
Issue number5
DOIs
StatePublished - Nov 1 2013

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Radiation
Radiotherapy
Neoplasms
Therapeutics
Preexisting Condition Coverage
Neoplasm Antigens
Immunotherapy
Immunosuppression
Cell Biology
Immune System
Immunity
Vaccination
Neoplasm Metastasis
T-Lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Harnessing the potential of radiation-induced immune modulation for cancer therapy. / Ahmed, Mansoor M.; Hodge, James W.; Guha, Chandan; Bernhard, Eric J.; Vikram, Bhadrasain; Coleman, C. Norman.

In: Cancer immunology research, Vol. 1, No. 5, 01.11.2013, p. 280-284.

Research output: Contribution to journalArticle

Ahmed, Mansoor M. ; Hodge, James W. ; Guha, Chandan ; Bernhard, Eric J. ; Vikram, Bhadrasain ; Coleman, C. Norman. / Harnessing the potential of radiation-induced immune modulation for cancer therapy. In: Cancer immunology research. 2013 ; Vol. 1, No. 5. pp. 280-284.
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