Halogen-magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

Felix Kopp, Stefan Wunderlich, Paul Knochel

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl·LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield.

Original languageEnglish (US)
Pages (from-to)2075-2077
Number of pages3
JournalChemical Communications
Issue number20
DOIs
StatePublished - Jan 1 2007

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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