Halogen-magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

Felix Kopp, Stefan Wunderlich, Paul Knochel

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl·LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield.

Original languageEnglish (US)
Pages (from-to)2075-2077
Number of pages3
JournalChemical Communications
Issue number20
DOIs
StatePublished - 2007
Externally publishedYes

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Halogens
Carboxylic Acids
Carboxylic acids
Magnesium

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Halogen-magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids. / Kopp, Felix; Wunderlich, Stefan; Knochel, Paul.

In: Chemical Communications, No. 20, 2007, p. 2075-2077.

Research output: Contribution to journalArticle

Kopp, Felix ; Wunderlich, Stefan ; Knochel, Paul. / Halogen-magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids. In: Chemical Communications. 2007 ; No. 20. pp. 2075-2077.
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