Guidelines for risk reduction when handling gametes from infectious patients seeking assisted reproductive technologies

Sangita K. Jindal, Richard G. Rawlins, Charles H. Muller, Erma Z. Drobnis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

According to the Americans with Disabilities Act (1990), couples with blood-borne viruses that lead to infectious disease cannot be denied fertility treatment as long as the direct threat to the health and safety of others can be reduced or eliminated by a modification of policies or procedures. Three types of infectious patients are commonly discussed in the context of fertility treatment: those with human immunodeficiency virus (HIV), hepatitis C or hepatitis B. Seventy-five per cent of hepatitis C or HIV positive men and women are in their reproductive years, and these couples look to assisted reproductive techniques for risk reduction in conceiving a pregnancy. In many cases, only one partner is infected. Legal and ethical questions about treatment of infectious patients aside, the question most asked by clinical embryologists and andrologists is: "What are the laboratory protocols for working with gametes and embryos from patients with infectious disease?" The serostatus of each patient is the key that informs appropriate treatments. This guidance document describes protocols for handling gametes from seroconcordant and serodiscordant couples with infectious disease. With minor modifications, infectious patients with stable disease status and undetectable or low viral load can be accommodated in the IVF laboratory.

Original languageEnglish (US)
JournalReproductive BioMedicine Online
DOIs
StateAccepted/In press - Jan 20 2016

Fingerprint

Assisted Reproductive Techniques
Risk Reduction Behavior
Germ Cells
Guidelines
Communicable Diseases
Hepatitis C
Fertility
HIV
Therapeutics
Viral Load
Hepatitis B
Embryonic Structures
Viruses
Safety
Pregnancy
Health

Keywords

  • Hepatitis B
  • Hepatitis C
  • HIV
  • IVF
  • Sperm purification
  • Standard precautions

ASJC Scopus subject areas

  • Reproductive Medicine
  • Developmental Biology

Cite this

Guidelines for risk reduction when handling gametes from infectious patients seeking assisted reproductive technologies. / Jindal, Sangita K.; Rawlins, Richard G.; Muller, Charles H.; Drobnis, Erma Z.

In: Reproductive BioMedicine Online, 20.01.2016.

Research output: Contribution to journalArticle

@article{d696b20e0c204e628da792f0b4e094ee,
title = "Guidelines for risk reduction when handling gametes from infectious patients seeking assisted reproductive technologies",
abstract = "According to the Americans with Disabilities Act (1990), couples with blood-borne viruses that lead to infectious disease cannot be denied fertility treatment as long as the direct threat to the health and safety of others can be reduced or eliminated by a modification of policies or procedures. Three types of infectious patients are commonly discussed in the context of fertility treatment: those with human immunodeficiency virus (HIV), hepatitis C or hepatitis B. Seventy-five per cent of hepatitis C or HIV positive men and women are in their reproductive years, and these couples look to assisted reproductive techniques for risk reduction in conceiving a pregnancy. In many cases, only one partner is infected. Legal and ethical questions about treatment of infectious patients aside, the question most asked by clinical embryologists and andrologists is: {"}What are the laboratory protocols for working with gametes and embryos from patients with infectious disease?{"} The serostatus of each patient is the key that informs appropriate treatments. This guidance document describes protocols for handling gametes from seroconcordant and serodiscordant couples with infectious disease. With minor modifications, infectious patients with stable disease status and undetectable or low viral load can be accommodated in the IVF laboratory.",
keywords = "Hepatitis B, Hepatitis C, HIV, IVF, Sperm purification, Standard precautions",
author = "Jindal, {Sangita K.} and Rawlins, {Richard G.} and Muller, {Charles H.} and Drobnis, {Erma Z.}",
year = "2016",
month = "1",
day = "20",
doi = "10.1016/j.rbmo.2016.04.015",
language = "English (US)",
journal = "Reproductive BioMedicine Online",
issn = "1472-6483",
publisher = "Elsevier",

}

TY - JOUR

T1 - Guidelines for risk reduction when handling gametes from infectious patients seeking assisted reproductive technologies

AU - Jindal, Sangita K.

AU - Rawlins, Richard G.

AU - Muller, Charles H.

AU - Drobnis, Erma Z.

PY - 2016/1/20

Y1 - 2016/1/20

N2 - According to the Americans with Disabilities Act (1990), couples with blood-borne viruses that lead to infectious disease cannot be denied fertility treatment as long as the direct threat to the health and safety of others can be reduced or eliminated by a modification of policies or procedures. Three types of infectious patients are commonly discussed in the context of fertility treatment: those with human immunodeficiency virus (HIV), hepatitis C or hepatitis B. Seventy-five per cent of hepatitis C or HIV positive men and women are in their reproductive years, and these couples look to assisted reproductive techniques for risk reduction in conceiving a pregnancy. In many cases, only one partner is infected. Legal and ethical questions about treatment of infectious patients aside, the question most asked by clinical embryologists and andrologists is: "What are the laboratory protocols for working with gametes and embryos from patients with infectious disease?" The serostatus of each patient is the key that informs appropriate treatments. This guidance document describes protocols for handling gametes from seroconcordant and serodiscordant couples with infectious disease. With minor modifications, infectious patients with stable disease status and undetectable or low viral load can be accommodated in the IVF laboratory.

AB - According to the Americans with Disabilities Act (1990), couples with blood-borne viruses that lead to infectious disease cannot be denied fertility treatment as long as the direct threat to the health and safety of others can be reduced or eliminated by a modification of policies or procedures. Three types of infectious patients are commonly discussed in the context of fertility treatment: those with human immunodeficiency virus (HIV), hepatitis C or hepatitis B. Seventy-five per cent of hepatitis C or HIV positive men and women are in their reproductive years, and these couples look to assisted reproductive techniques for risk reduction in conceiving a pregnancy. In many cases, only one partner is infected. Legal and ethical questions about treatment of infectious patients aside, the question most asked by clinical embryologists and andrologists is: "What are the laboratory protocols for working with gametes and embryos from patients with infectious disease?" The serostatus of each patient is the key that informs appropriate treatments. This guidance document describes protocols for handling gametes from seroconcordant and serodiscordant couples with infectious disease. With minor modifications, infectious patients with stable disease status and undetectable or low viral load can be accommodated in the IVF laboratory.

KW - Hepatitis B

KW - Hepatitis C

KW - HIV

KW - IVF

KW - Sperm purification

KW - Standard precautions

UR - http://www.scopus.com/inward/record.url?scp=84971658808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971658808&partnerID=8YFLogxK

U2 - 10.1016/j.rbmo.2016.04.015

DO - 10.1016/j.rbmo.2016.04.015

M3 - Article

C2 - 27235103

AN - SCOPUS:84971658808

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

ER -