Guide RNA acrobatics: the one-for-two shuffle

U. Thomas Meier

doi:10.1101/gad.349285.121

Guide RNA acrobatics: the one-for-two shuffle

U. Thomas Meier

Cell Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of Genes & Development, Jády and colleagues (pp. 70-83) identify a novel mechanism by which a single guide RNA hairpin can specify two uridines adjacent to each other or separated by 1 nt; i.e., one for two or guide RNA acrobatics.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Genes & development
Volume	36
Issue number	1-2
DOIs	https://doi.org/10.1101/gad.349285.121
State	Published - Jan 1 2022

Keywords

RNA-guided RNA modification
RNA–RNA interaction
box H/ACA RNAs
guide RNA acrobatics
pseudouridine
pseudouridylation

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.349285.121

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title = "Guide RNA acrobatics: the one-for-two shuffle",

abstract = "RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of Genes & Development, J{\'a}dy and colleagues (pp. 70-83) identify a novel mechanism by which a single guide RNA hairpin can specify two uridines adjacent to each other or separated by 1 nt; i.e., one for two or guide RNA acrobatics.",

keywords = "RNA-guided RNA modification, RNA–RNA interaction, box H/ACA RNAs, guide RNA acrobatics, pseudouridine, pseudouridylation",

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AB - RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of Genes & Development, Jády and colleagues (pp. 70-83) identify a novel mechanism by which a single guide RNA hairpin can specify two uridines adjacent to each other or separated by 1 nt; i.e., one for two or guide RNA acrobatics.

KW - RNA-guided RNA modification

KW - RNA–RNA interaction

KW - box H/ACA RNAs

KW - guide RNA acrobatics

KW - pseudouridine

KW - pseudouridylation

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Guide RNA acrobatics: the one-for-two shuffle

Abstract

Keywords

ASJC Scopus subject areas

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