Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice

Yingjie Wu, Chengyu Liu, Hui Sun, Archana Vijayakumar, Pejman Raeisi Giglou, Ruifang Qiao, Joshua Oppenheimer, Shoshana Yakar, Derek LeRoith

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Insulin, growth hormone (GH), and insulin-like growth factor-1 (IGF-1) play key roles in the regulation of β cell growth and function. Although β cells express the GH receptor, the direct effects of GH on β cells remain largely unknown. Here we have employed a rat insulin II promoter-driven (RIP-driven) Cre recombinase to disrupt the GH receptor in β cells (βGHRKO). βGHRKO mice fed a standard chow diet exhibited impaired glucose-stimulated insulin secretion but had no changes in β cell mass. When challenged with a high-fat diet, βGHRKO mice showed evidence of a β cell secretory defect, with further deterioration of glucose homeostasis indicated by their altered glucose tolerance and blunted glucose-stimulated insulin secretion. Interestingly, βGHRKO mice were impaired in β cell hyperplasia in response to a high-fat diet, with decreased β cell proliferation and overall reduced β cell mass. Therefore, GH receptor plays critical roles in glucose-stimulated insulin secretion and β cell compensation in response to a high-fat diet.

Original languageEnglish (US)
Pages (from-to)2422-2426
Number of pages5
JournalJournal of Clinical Investigation
Volume121
Issue number6
DOIs
StatePublished - Jun 1 2011

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wu, Y., Liu, C., Sun, H., Vijayakumar, A., Giglou, P. R., Qiao, R., Oppenheimer, J., Yakar, S., & LeRoith, D. (2011). Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. Journal of Clinical Investigation, 121(6), 2422-2426. https://doi.org/10.1172/JCI45027