Growth factor regulation of neuronal development

Mark F. Mehler, John A. Kessler

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Recent experimental investigations have redefined the spectrum of growth factors and developmental signalling pathways that are necessary to orchestrate the growth and differentiation of regional neuronal subpopulations. Gene knockout studies of the classic neurotrophins and their high-affinity tyrosine kinase (Trk) receptors have refined our definition of the cellular mechanisms and target populations of these neuronotrophic factors. Recognition of the significant parallels that exist between neuropoiesis and hematolymphopoiesis has fostered our study of the range and cellular actions of these hemopoietins in neuronal development. In addition, by activating receptor subunits that possess serine/threonine activity, bone morphogenetic proteins of the transforming growth factor-β superfamily exhibit complex spatiotemporal regulation of regional neuronal subpopulations. These collective observations suggest that a complex hierarchy of epigenetic signals is required for the growth and maturation of regional neuronal lineage species in the central and peripheral mammalian nervous system.

Original languageEnglish (US)
Pages (from-to)180-195
Number of pages16
JournalDevelopmental Neuroscience
Volume16
Issue number3-4
DOIs
Publication statusPublished - Jan 1 1994

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Keywords

  • Bone morphogenetic proteins
  • Colony-stimulating factors
  • Cytokines
  • Differentiation
  • Hematolymphopoietic
  • Interleukins
  • Neurotrophins
  • Signal transduction
  • Tyrosine kinase

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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