Abstract
Hyperglycemia causes excessive amounts of irreversible advanced glycosylation end products (AGEPs) to accumulate on long-lived extracellular matrix proteins and probably also on DNA in tissues that develop diabetic complications. AGEPs induce permanent abnormalities in extracellular protein cross-linking, cell-matrix interactions, and DNA structure in vitro. Pharmacologically inhibiting AGEP formation in long-term diabetic animals prevents both retinal capillary pathology and thickening of the glomerular basement membrane.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-166 |
| Number of pages | 8 |
| Journal | Annual Review of Medicine |
| Volume | 42 |
| DOIs | |
| State | Published - 1991 |
| Externally published | Yes |
Keywords
- Aminoguanidine
- Coagulation
- DNA
- Diabetes
- Extracellular matrix
- Growth factors
- Macrophages
- Pharmacology
- Therapy
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
