Glycosylation products as toxic mediators of diabetic complications

Michael Brownlee

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Hyperglycemia causes excessive amounts of irreversible advanced glycosylation end products (AGEPs) to accumulate on long-lived extracellular matrix proteins and probably also on DNA in tissues that develop diabetic complications. AGEPs induce permanent abnormalities in extracellular protein cross-linking, cell-matrix interactions, and DNA structure in vitro. Pharmacologically inhibiting AGEP formation in long-term diabetic animals prevents both retinal capillary pathology and thickening of the glomerular basement membrane.

Original languageEnglish (US)
Pages (from-to)159-166
Number of pages8
JournalAnnual Review of Medicine
Volume42
StatePublished - 1991

Fingerprint

Glycosylation
Advanced Glycosylation End Products
Poisons
Diabetes Complications
Glomerular Basement Membrane
Extracellular Matrix Proteins
DNA
Pathology
Cell Communication
Hyperglycemia
Animals
Tissue
Proteins

Keywords

  • Aminoguanidine
  • Coagulation
  • Diabetes
  • DNA
  • Extracellular matrix
  • Growth factors
  • Macrophages
  • Pharmacology
  • Therapy

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Glycosylation products as toxic mediators of diabetic complications. / Brownlee, Michael.

In: Annual Review of Medicine, Vol. 42, 1991, p. 159-166.

Research output: Contribution to journalArticle

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