Glycolipid activators of invariant NKT cells as vaccine adjuvants

Shalu Sharma, Pooja Arora, Steven A. Porcelli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Natural Killer T cells (NKT cells) are a subpopulation of T lymphocytes with unique phenotypic properties and a remarkably broad range of immune effector and regulatory functions. One subset of these cells, known as invariant NKT cells (iNKT cells), has become a significant focus in the search for new and better ways to enhance immunotherapies and vaccination. These unconventional T cells are characterized by their ability to be specifically activated by a range of foreign and self-derived glycolipid antigens presented by CD1d, an MHC class I-related antigen presenting molecule that has evolved to bind and present lipid antigens. The development of synthetic α-galactosylceramides as a family of powerful glycolipid agonists for iNKT cells has led to approaches for augmenting a wide variety of immune responses, including those involved in vaccination against infections and cancers. Here we review the basic background biology of iNKT cells that is relevant to their potential for improving immune responses, and summarize recent work supporting the further development of glycolipid activators of iNKT cells as a new class of vaccine adjuvants.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalImmunogenetics
DOIs
StateAccepted/In press - Jul 5 2016

Fingerprint

Natural Killer T-Cells
Glycolipids
Vaccines
CD1d Antigen
Vaccination
Galactosylceramides
T-Lymphocytes
Histocompatibility Antigens Class I
Immunotherapy
Lipids
Antigens
Infection
Neoplasms

Keywords

  • Antigen presenting cells
  • CD1d
  • Cytokine
  • Glycolipid
  • NKT cell

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Glycolipid activators of invariant NKT cells as vaccine adjuvants. / Sharma, Shalu; Arora, Pooja; Porcelli, Steven A.

In: Immunogenetics, 05.07.2016, p. 1-14.

Research output: Contribution to journalArticle

@article{75364b2b41cd49a2b80e86c98761bf3f,
title = "Glycolipid activators of invariant NKT cells as vaccine adjuvants",
abstract = "Natural Killer T cells (NKT cells) are a subpopulation of T lymphocytes with unique phenotypic properties and a remarkably broad range of immune effector and regulatory functions. One subset of these cells, known as invariant NKT cells (iNKT cells), has become a significant focus in the search for new and better ways to enhance immunotherapies and vaccination. These unconventional T cells are characterized by their ability to be specifically activated by a range of foreign and self-derived glycolipid antigens presented by CD1d, an MHC class I-related antigen presenting molecule that has evolved to bind and present lipid antigens. The development of synthetic α-galactosylceramides as a family of powerful glycolipid agonists for iNKT cells has led to approaches for augmenting a wide variety of immune responses, including those involved in vaccination against infections and cancers. Here we review the basic background biology of iNKT cells that is relevant to their potential for improving immune responses, and summarize recent work supporting the further development of glycolipid activators of iNKT cells as a new class of vaccine adjuvants.",
keywords = "Antigen presenting cells, CD1d, Cytokine, Glycolipid, NKT cell",
author = "Shalu Sharma and Pooja Arora and Porcelli, {Steven A.}",
year = "2016",
month = "7",
day = "5",
doi = "10.1007/s00251-016-0925-y",
language = "English (US)",
pages = "1--14",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Glycolipid activators of invariant NKT cells as vaccine adjuvants

AU - Sharma, Shalu

AU - Arora, Pooja

AU - Porcelli, Steven A.

PY - 2016/7/5

Y1 - 2016/7/5

N2 - Natural Killer T cells (NKT cells) are a subpopulation of T lymphocytes with unique phenotypic properties and a remarkably broad range of immune effector and regulatory functions. One subset of these cells, known as invariant NKT cells (iNKT cells), has become a significant focus in the search for new and better ways to enhance immunotherapies and vaccination. These unconventional T cells are characterized by their ability to be specifically activated by a range of foreign and self-derived glycolipid antigens presented by CD1d, an MHC class I-related antigen presenting molecule that has evolved to bind and present lipid antigens. The development of synthetic α-galactosylceramides as a family of powerful glycolipid agonists for iNKT cells has led to approaches for augmenting a wide variety of immune responses, including those involved in vaccination against infections and cancers. Here we review the basic background biology of iNKT cells that is relevant to their potential for improving immune responses, and summarize recent work supporting the further development of glycolipid activators of iNKT cells as a new class of vaccine adjuvants.

AB - Natural Killer T cells (NKT cells) are a subpopulation of T lymphocytes with unique phenotypic properties and a remarkably broad range of immune effector and regulatory functions. One subset of these cells, known as invariant NKT cells (iNKT cells), has become a significant focus in the search for new and better ways to enhance immunotherapies and vaccination. These unconventional T cells are characterized by their ability to be specifically activated by a range of foreign and self-derived glycolipid antigens presented by CD1d, an MHC class I-related antigen presenting molecule that has evolved to bind and present lipid antigens. The development of synthetic α-galactosylceramides as a family of powerful glycolipid agonists for iNKT cells has led to approaches for augmenting a wide variety of immune responses, including those involved in vaccination against infections and cancers. Here we review the basic background biology of iNKT cells that is relevant to their potential for improving immune responses, and summarize recent work supporting the further development of glycolipid activators of iNKT cells as a new class of vaccine adjuvants.

KW - Antigen presenting cells

KW - CD1d

KW - Cytokine

KW - Glycolipid

KW - NKT cell

UR - http://www.scopus.com/inward/record.url?scp=84976891113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976891113&partnerID=8YFLogxK

U2 - 10.1007/s00251-016-0925-y

DO - 10.1007/s00251-016-0925-y

M3 - Article

C2 - 27377623

AN - SCOPUS:84976891113

SP - 1

EP - 14

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

ER -