Glucose transporter gene expression in early mouse embryos

Aileen Hogan; Susan Heyner; Maureen J. Charron; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Bernard Thorens; Gilbert A. Schultz

Glucose transporter gene expression in early mouse embryos

Aileen Hogan, Susan Heyner, Maureen J. Charron, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Bernard Thorens, Gilbert A. Schultz

Biochemistry

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

Abstract

The glucose transporter (GLUT) isoforms responsible for glucose uptake in early mouse embryos have been identified. GLUT 1, the isoform present in nearly every tissue examined including adult brain and erythrocytes, is expressed throughout preimplantation development. GLUT 2, which is normally present in adult liver, kidney, intestine and pancreatic β cells is expressed from the 8-cell stage onward. GLUT 4, an insulin-recruitable isoform, which is expressed in adult fat and muscle, is not expressed at any stage of preimplantation development or in early postimplantation stage embryos. Genetic mapping studies of glucose transporters in the mouse show that Glut-1 is located on chromosome 4, Glut-2 on chromosome 3, Glut-3 on chromosome 6, and Glut-4 on chromosome 11.

Original language	English (US)
Pages (from-to)	363-372
Number of pages	10
Journal	Development
Volume	113
Issue number	1
State	Published - Sep 1991

Keywords

Glucose transporters
Mouse embryos
Polymerase chain reaction

ASJC Scopus subject areas

Molecular Biology
Developmental Biology

Cite this

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title = "Glucose transporter gene expression in early mouse embryos",

abstract = "The glucose transporter (GLUT) isoforms responsible for glucose uptake in early mouse embryos have been identified. GLUT 1, the isoform present in nearly every tissue examined including adult brain and erythrocytes, is expressed throughout preimplantation development. GLUT 2, which is normally present in adult liver, kidney, intestine and pancreatic β cells is expressed from the 8-cell stage onward. GLUT 4, an insulin-recruitable isoform, which is expressed in adult fat and muscle, is not expressed at any stage of preimplantation development or in early postimplantation stage embryos. Genetic mapping studies of glucose transporters in the mouse show that Glut-1 is located on chromosome 4, Glut-2 on chromosome 3, Glut-3 on chromosome 6, and Glut-4 on chromosome 11.",

keywords = "Glucose transporters, Mouse embryos, Polymerase chain reaction",

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language = "English (US)",

volume = "113",

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T1 - Glucose transporter gene expression in early mouse embryos

AU - Hogan, Aileen

AU - Heyner, Susan

AU - Charron, Maureen J.

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Thorens, Bernard

AU - Schultz, Gilbert A.

PY - 1991/9

Y1 - 1991/9

N2 - The glucose transporter (GLUT) isoforms responsible for glucose uptake in early mouse embryos have been identified. GLUT 1, the isoform present in nearly every tissue examined including adult brain and erythrocytes, is expressed throughout preimplantation development. GLUT 2, which is normally present in adult liver, kidney, intestine and pancreatic β cells is expressed from the 8-cell stage onward. GLUT 4, an insulin-recruitable isoform, which is expressed in adult fat and muscle, is not expressed at any stage of preimplantation development or in early postimplantation stage embryos. Genetic mapping studies of glucose transporters in the mouse show that Glut-1 is located on chromosome 4, Glut-2 on chromosome 3, Glut-3 on chromosome 6, and Glut-4 on chromosome 11.

AB - The glucose transporter (GLUT) isoforms responsible for glucose uptake in early mouse embryos have been identified. GLUT 1, the isoform present in nearly every tissue examined including adult brain and erythrocytes, is expressed throughout preimplantation development. GLUT 2, which is normally present in adult liver, kidney, intestine and pancreatic β cells is expressed from the 8-cell stage onward. GLUT 4, an insulin-recruitable isoform, which is expressed in adult fat and muscle, is not expressed at any stage of preimplantation development or in early postimplantation stage embryos. Genetic mapping studies of glucose transporters in the mouse show that Glut-1 is located on chromosome 4, Glut-2 on chromosome 3, Glut-3 on chromosome 6, and Glut-4 on chromosome 11.

KW - Glucose transporters

KW - Mouse embryos

KW - Polymerase chain reaction

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Glucose transporter gene expression in early mouse embryos

Abstract

Keywords

ASJC Scopus subject areas

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