Glucose transporter gene expression in early mouse embryos

Aileen Hogan, Susan Heyner, Maureen J. Charron, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Bernard Thorens, Gilbert A. Schultz

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

The glucose transporter (GLUT) isoforms responsible for glucose uptake in early mouse embryos have been identified. GLUT 1, the isoform present in nearly every tissue examined including adult brain and erythrocytes, is expressed throughout preimplantation development. GLUT 2, which is normally present in adult liver, kidney, intestine and pancreatic β cells is expressed from the 8-cell stage onward. GLUT 4, an insulin-recruitable isoform, which is expressed in adult fat and muscle, is not expressed at any stage of preimplantation development or in early postimplantation stage embryos. Genetic mapping studies of glucose transporters in the mouse show that Glut-1 is located on chromosome 4, Glut-2 on chromosome 3, Glut-3 on chromosome 6, and Glut-4 on chromosome 11.

Original languageEnglish (US)
Pages (from-to)363-372
Number of pages10
JournalDevelopment
Volume113
Issue number1
StatePublished - Sep 1991

Fingerprint

Facilitative Glucose Transport Proteins
Embryonic Structures
Gene Expression
Protein Isoforms
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 3
Intestines
Erythrocytes
Fats
Insulin
Kidney
Glucose
Muscles
Liver
Brain

Keywords

  • Glucose transporters
  • Mouse embryos
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Hogan, A., Heyner, S., Charron, M. J., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., ... Schultz, G. A. (1991). Glucose transporter gene expression in early mouse embryos. Development, 113(1), 363-372.

Glucose transporter gene expression in early mouse embryos. / Hogan, Aileen; Heyner, Susan; Charron, Maureen J.; Copeland, Neal G.; Gilbert, Debra J.; Jenkins, Nancy A.; Thorens, Bernard; Schultz, Gilbert A.

In: Development, Vol. 113, No. 1, 09.1991, p. 363-372.

Research output: Contribution to journalArticle

Hogan, A, Heyner, S, Charron, MJ, Copeland, NG, Gilbert, DJ, Jenkins, NA, Thorens, B & Schultz, GA 1991, 'Glucose transporter gene expression in early mouse embryos', Development, vol. 113, no. 1, pp. 363-372.
Hogan A, Heyner S, Charron MJ, Copeland NG, Gilbert DJ, Jenkins NA et al. Glucose transporter gene expression in early mouse embryos. Development. 1991 Sep;113(1):363-372.
Hogan, Aileen ; Heyner, Susan ; Charron, Maureen J. ; Copeland, Neal G. ; Gilbert, Debra J. ; Jenkins, Nancy A. ; Thorens, Bernard ; Schultz, Gilbert A. / Glucose transporter gene expression in early mouse embryos. In: Development. 1991 ; Vol. 113, No. 1. pp. 363-372.
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