Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation

Khulan Batbayar, Lincoln Liu, Catherine M. Rose, Ashley K. Boyle, Jonathan R. Manning, Amanda J. Drake

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

ABSTRACT: Glucocorticoids are widely used in threatened preterm labor to promote maturation in many organ systems in preterm babies and have significant beneficial effects on morbidity and mortality. We performed transcriptional profiling in fetal liver in a rat model of prenatal glucocorticoid exposure and identified marked gene expression changes in heme biosynthesis, utilization, and degradation pathways in late gestation. These changes in gene expression associated with alterations in DNA methylation and with a reduction in hepatic heme concentration. There were no persistent differences in gene expression, DNA methylation, or heme concentrations at 4 weeks of age, suggesting that these are transient effects. Our findings are consistent with glucocorticoid-induced accelerated maturation of the haematopoietic system and support the hypothesis that glucocorticoids can drive changes in gene expression in association with alterations in DNA methylation.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalEpigenetics
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Fingerprint

DNA Methylation
Heme
Glucocorticoids
Gene Expression
Liver
Hematopoietic System
Premature Obstetric Labor
Morbidity
Pregnancy
Mortality

Keywords

  • DNA methylation
  • glucocorticoids
  • heme
  • liver
  • prenatal

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

Cite this

Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation. / Batbayar, Khulan; Liu, Lincoln; Rose, Catherine M.; Boyle, Ashley K.; Manning, Jonathan R.; Drake, Amanda J.

In: Epigenetics, Vol. 11, No. 2, 01.02.2016, p. 103-109.

Research output: Contribution to journalArticle

Batbayar, Khulan ; Liu, Lincoln ; Rose, Catherine M. ; Boyle, Ashley K. ; Manning, Jonathan R. ; Drake, Amanda J. / Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation. In: Epigenetics. 2016 ; Vol. 11, No. 2. pp. 103-109.
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