Glomerulosclerosis in aging humans is not influenced by gender

Joel Neugarten, G. Gallo, S. Silbiger, B. Kasiske

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Aging male rats develop progressive glomerulosclerosis, proteinuria, and loss of renal function, whereas females are remarkably resistant to the development of these abnormalities. Although sex hormones appear to contribute to gender-related differences in the development of glomerulosclerosis in aging rats, it is not clear that sexual dimorphism characterizes glomerular obsolescence in aging humans. To study this question further, the glomerular histology of males and females ranging in age from infancy to 90 years was compared in 250 autopsy specimens. We found no differences between the sexes in the development of glomerulosclerosis in aging humans. These data disprove the hypothesis that testosterone is an important factor contributing to progressive glomerulosclerosis in aging men. Conversely, any renoprotective effects of estrogen would be limited by the onset of menopause because significant glomerulosclerosis did not develop until after the age of 50 years.

Original languageEnglish (US)
Pages (from-to)884-888
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume34
Issue number5
StatePublished - 1999

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Sexual Development
Gonadal Steroid Hormones
Menopause
Proteinuria
Sex Characteristics
Testosterone
Autopsy
Histology
Estrogens
Kidney

Keywords

  • Gender
  • Glomerulosclerosis
  • Glomerulus
  • Senescence

ASJC Scopus subject areas

  • Nephrology

Cite this

Glomerulosclerosis in aging humans is not influenced by gender. / Neugarten, Joel; Gallo, G.; Silbiger, S.; Kasiske, B.

In: American Journal of Kidney Diseases, Vol. 34, No. 5, 1999, p. 884-888.

Research output: Contribution to journalArticle

Neugarten, J, Gallo, G, Silbiger, S & Kasiske, B 1999, 'Glomerulosclerosis in aging humans is not influenced by gender', American Journal of Kidney Diseases, vol. 34, no. 5, pp. 884-888.
Neugarten, Joel ; Gallo, G. ; Silbiger, S. ; Kasiske, B. / Glomerulosclerosis in aging humans is not influenced by gender. In: American Journal of Kidney Diseases. 1999 ; Vol. 34, No. 5. pp. 884-888.
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