Glomerulonephritis in bacterial endocarditis

Joel Neugarten, David S. Baldwin

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

The introduction of antibiotic therapy and changing epidemiologic patterns have altered the nature of glomerulonephritis as it occurs during the course of bacterial endocarditis. Observations made predominantly in the pre-antibiotic era suggested that infections with less virulent organisms, by virtue of their indolent subacute course, favored an antibody response predisposing to immune complex glomerulonephritis. Although antibiotic prophylaxis and therapy have reduced the incidence of both Streptococcus viridans bacterial endocarditis and concomitant glomerulonephritis, Staphylococcus aureus has become a major cause of acute bacterial endocarditis with a high incidence of glomerulonephritis. Parenteral drug abuse itself, which has emerged as a major factor predisposing to endocarditis, may also favor the development of glomerulonephritis. The course of glomerulonephritis has been altered in association with these changes in etiology and epidemiology. This review summarizes the clinical and morphologic features of glomerulonephritis as it currently occurs during the course of bacterial endocarditis.

Original languageEnglish (US)
Pages (from-to)297-304
Number of pages8
JournalThe American journal of medicine
Volume77
Issue number2
DOIs
StatePublished - 1984
Externally publishedYes

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Bacterial Endocarditis
Glomerulonephritis
Intravenous Substance Abuse
Anti-Bacterial Agents
Viridans Streptococci
Antibiotic Prophylaxis
Incidence
Endocarditis
Antigen-Antibody Complex
Causality
Antibody Formation
Staphylococcus aureus
Epidemiology
Therapeutics
Infection

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Glomerulonephritis in bacterial endocarditis. / Neugarten, Joel; Baldwin, David S.

In: The American journal of medicine, Vol. 77, No. 2, 1984, p. 297-304.

Research output: Contribution to journalArticle

Neugarten, Joel ; Baldwin, David S. / Glomerulonephritis in bacterial endocarditis. In: The American journal of medicine. 1984 ; Vol. 77, No. 2. pp. 297-304.
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