Glomerular infiltration by CXCR3+ ICOS+ activated T cells in chronic allograft nephropathy with transplant glomerulopathy

Enver Akalin, S. Dikman, B. Murphy, J. S. Bromberg, W. W. Hancock

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

The pathogeneses of chronic allograft nephropathy (CAN), a leading cause of allograft failure, and one of its complications, transplant glomerulopathy (TGP), are unknown. Immunohistologic analysis of human renal transplant biopsies showed expression of inducible costimulator (ICOS), the chemokine receptor CXCR3, and its ligands, Mig and IP-10, by intraglomerular and periglomerular leukocytes in biopsies with CAN and TGP but not CAN alone. ICOS and CXCR3 are both characteristics of activated, effector T cells, suggesting different pathogenetic mechanisms underlying TGP vs. CAN. We conclude that targeting of specific chemokine and chemokine receptor pathways and/or ICOS may have clinical application in the prevention and treatment of TGP.

Original languageEnglish (US)
Pages (from-to)1116-1120
Number of pages5
JournalAmerican Journal of Transplantation
Volume3
Issue number9
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Keywords

  • CXCR3
  • Chemokines
  • Chronic allograft nephropathy
  • ICOS
  • Transplant glomerulopathy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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