Getting to the Ncor of HSC emergence

Research output: Contribution to journalComment/debate

Abstract

In this issue of Blood, Wei et al describe how the nuclear corepressor ncor2 helps keep hemogenic gene expression at just the right level necessary for hematopoietic stem and progenitor cell (HSPC) emergence.1Forming an HSPC requires a Goldilocks touch in that too much or too little signal can inhibit their formation from specialized hemogenic endothelial cells. These results shed light on a critical factor in establishing proper balance during HSPC formation.

Original languageEnglish (US)
Pages (from-to)1541-1542
Number of pages2
JournalBlood
Volume124
Issue number10
DOIs
StatePublished - Jan 1 2014

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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