Getting rid of the catastrophe: Frontier research in infantile spasms

Research output: Contribution to journalArticle

Abstract

Infantile spasms (IS) are an age-specific epileptic syndrome with overall poor outcome and are recognized as one of the 'catastrophic epilepsies'. Current conventional therapies including adrenocorticotropic hormone and vigabatrin often fail to control the spasms and improve the long-term outcome, especially in cases with structural/metabolic etiologies. To improve this situation, new treatments with a disease modifying potential must be identi-fied. Recent translational studies have led to the development of several animal models of IS that reflect their multiple etiologies. Among these, the multiple hit model has been used to screen new promising therapies that, in the future, may be explored in clinical trials.

Original languageEnglish (US)
Pages (from-to)19-29
Number of pages11
JournalEpilepsy and Seizure
Volume6
Issue number1
DOIs
StatePublished - 2013

Fingerprint

Infantile Spasms
Research
Vigabatrin
Spasm
Adrenocorticotropic Hormone
Epilepsy
Therapeutics
Animal Models
Clinical Trials

Keywords

  • Animal model
  • Infantile spasms
  • Medical treatment
  • West syndrome

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Getting rid of the catastrophe : Frontier research in infantile spasms. / Ono, Tomonori; Galanopoulou, Aristea S.; Moshe, Solomon L.

In: Epilepsy and Seizure, Vol. 6, No. 1, 2013, p. 19-29.

Research output: Contribution to journalArticle

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