Getting rid of the catastrophe: Frontier research in infantile spasms

Research output: Contribution to journalReview articlepeer-review


Infantile spasms (IS) are an age-specific epileptic syndrome with overall poor outcome and are recognized as one of the 'catastrophic epilepsies'. Current conventional therapies including adrenocorticotropic hormone and vigabatrin often fail to control the spasms and improve the long-term outcome, especially in cases with structural/metabolic etiologies. To improve this situation, new treatments with a disease modifying potential must be identi-fied. Recent translational studies have led to the development of several animal models of IS that reflect their multiple etiologies. Among these, the multiple hit model has been used to screen new promising therapies that, in the future, may be explored in clinical trials.

Original languageEnglish (US)
Pages (from-to)19-29
Number of pages11
JournalEpilepsy and Seizure
Issue number1
StatePublished - 2013


  • Animal model
  • Infantile spasms
  • Medical treatment
  • West syndrome

ASJC Scopus subject areas

  • Clinical Neurology


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