Geographical Distribution and Risk Association of Human Papillomavirus Genotype 52-Variant Lineages

Chuqing Zhang, Jong Sup Park, Grce Magdalena, Samantha Hibbitts, Joel M. Palefsky, Ryo Konno, Karen K. Smith-McCune, Lucia Giovannelli, Tang Yuan Chu, María Alejandra Picconi, Patricia Piña-Sánchez, Wannapa Settheetham-Ishida, Francois Coutlée, Federico De Marco, Yin Ling Woo, Wendy C.S. Ho, Martin C.S. Wong, Mike Z. Chirenje, Tsitsi Magure, Anna Barbara MoscickiIvan Sabol, Alison N. Fiander, Zigui Chen, Martin C.W. Chan, Tak Hong Cheung, Robert D. Burk, Paul K.S. Chan

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Human papillomavirus (HPV) genotype 52 is commonly found in Asian cases of cervical cancer but is rare elsewhere. Analysis of 611 isolates collected worldwide revealed a remarkable geographical distribution, with lineage B predominating in Asia (89.0% vs 0%-5.5%; Pcorrected <. 001), whereas lineage A predominated in Africa, the Americas, and Europe. We propose that the name "Asian lineage" be used to denote lineage B, to signify this feature. Preliminary analysis suggested a higher disease risk for lineage B, although ethnogeographical confounders could not be excluded. Further studies are warranted to verify whether the reported high attribution of disease to HPV52 in Asia is due to the high prevalence of lineage B.

Original languageEnglish (US)
Pages (from-to)1600-1604
Number of pages5
JournalJournal of Infectious Diseases
Volume210
Issue number10
DOIs
StatePublished - Nov 15 2014

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Keywords

  • Asia.
  • HPV
  • cervical cancer
  • oncogenic risk
  • phylogeny

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Zhang, C., Park, J. S., Magdalena, G., Hibbitts, S., Palefsky, J. M., Konno, R., Smith-McCune, K. K., Giovannelli, L., Chu, T. Y., Picconi, M. A., Piña-Sánchez, P., Settheetham-Ishida, W., Coutlée, F., De Marco, F., Woo, Y. L., Ho, W. C. S., Wong, M. C. S., Chirenje, M. Z., Magure, T., ... Chan, P. K. S. (2014). Geographical Distribution and Risk Association of Human Papillomavirus Genotype 52-Variant Lineages. Journal of Infectious Diseases, 210(10), 1600-1604. https://doi.org/10.1093/infdis/jiu310