Genotoxic effects of intragastrically administered benzo[a] pyrene in rat liver and intestinal cells

Erik Mullaart, Marinus Buytenhek, Adriaan Brouwer, Paul H.M. Lohman, Jan Vijg

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The genotoxic effects of intragastrically administered benzo[a] pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a considerable number of alkali-labile sites was present in the DNA of both intestinal cells and parenchymal liver cells, but not in that of non-parenchymal liver cells. The possibility is discussed that these sites were induced by radical intermediates, generated during the metabolization of BaP.

Original languageEnglish (US)
Pages (from-to)393-395
Number of pages3
JournalCarcinogenesis
Volume10
Issue number2
DOIs
StatePublished - Feb 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research

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