Genotoxic effects of intragastrically administered benzo[a] pyrene in rat liver and intestinal cells

Erik Mullaart; Marinus Buytenhek; Adriaan Brouwer; Paul H.M. Lohman; Jan Vijg

doi:10.1093/carcin/10.2.393

Genotoxic effects of intragastrically administered benzo[a] pyrene in rat liver and intestinal cells

Erik Mullaart, Marinus Buytenhek, Adriaan Brouwer, Paul H.M. Lohman, Jan Vijg

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Abstract

The genotoxic effects of intragastrically administered benzo[a] pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a considerable number of alkali-labile sites was present in the DNA of both intestinal cells and parenchymal liver cells, but not in that of non-parenchymal liver cells. The possibility is discussed that these sites were induced by radical intermediates, generated during the metabolization of BaP.

Original language	English (US)
Pages (from-to)	393-395
Number of pages	3
Journal	Carcinogenesis
Volume	10
Issue number	2
DOIs	https://doi.org/10.1093/carcin/10.2.393
State	Published - Feb 1989
Externally published	Yes

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10.1093/carcin/10.2.393

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title = "Genotoxic effects of intragastrically administered benzo[a] pyrene in rat liver and intestinal cells",

abstract = "The genotoxic effects of intragastrically administered benzo[a] pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a considerable number of alkali-labile sites was present in the DNA of both intestinal cells and parenchymal liver cells, but not in that of non-parenchymal liver cells. The possibility is discussed that these sites were induced by radical intermediates, generated during the metabolization of BaP.",

author = "Erik Mullaart and Marinus Buytenhek and Adriaan Brouwer and Lohman, {Paul H.M.} and Jan Vijg",

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AU - Mullaart, Erik

AU - Buytenhek, Marinus

AU - Brouwer, Adriaan

AU - Lohman, Paul H.M.

AU - Vijg, Jan

PY - 1989/2

Y1 - 1989/2

N2 - The genotoxic effects of intragastrically administered benzo[a] pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a considerable number of alkali-labile sites was present in the DNA of both intestinal cells and parenchymal liver cells, but not in that of non-parenchymal liver cells. The possibility is discussed that these sites were induced by radical intermediates, generated during the metabolization of BaP.

AB - The genotoxic effects of intragastrically administered benzo[a] pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a considerable number of alkali-labile sites was present in the DNA of both intestinal cells and parenchymal liver cells, but not in that of non-parenchymal liver cells. The possibility is discussed that these sites were induced by radical intermediates, generated during the metabolization of BaP.

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JO - Carcinogenesis

JF - Carcinogenesis

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ER -

Genotoxic effects of intragastrically administered benzo[a] pyrene in rat liver and intestinal cells

Abstract

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